N115 Midterm Study Questions and
Answers
Which of the following does NOT influence the degree to which a drug moves by passive diffusion across
membranes?
a. the lipophilicity of a drug
b. the degree of gastric absorption
c. the proportion of drug that is charged
d. the concentration gradien...
A drug that is highly extracted by the liver (hepatic first pass effect) will have which one of the following?
a. long half-life (t1/2)
b. low renal clearance
c. low oral bioavailability
d. high volume of distribution (Vd) - Ans:✔✔-ANS: C
Genetic differences in drug CYP450 enzymes may lead to all of the following except:
a. increased adverse effects
b. increased drug toxicity
c. increased drug interactions
d. increased rate of absorption in the gut - Ans:✔✔-ANS: D
Why are polar groups added to lipid soluble drugs by hepatic enzymes during Phase I and Phase II
reactions?
a. to produce slower absorption and a longer half-life
b. to increase the concentration in the plasma compartment after oral administration
c. to prevent passive reabsorption and promote renal elimination
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