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MGY378 - Picornaviridae Exam Study Set
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MGY378 - Picornaviridae ExamStudy Set
What are the two major categories of virus that fall under Picornaviridae? - Answer
Rhinoviruses and Enteroviruses
How are these viruses mainly transmitted? - Answer Through Fecal-Oral and respiratory
methods of transmission
What can the viruses in this family cause? - Answer Upper respiratory
tract/gastrointestinal infections and poliomyelitis
Are any viruses in these families vaccine-preventable? - Answer Hepatitis A and Polio
are, but there's no treatment available for the other more well known viruses like
foot-and-mouth-disease.
Where does the virus replicate? - Answer In the cytoplasm of the respiratory and
gastrointestinal endothelial lining (as well as in some neuronal cells)
How do the viruses of this family undergo translation? - Answer Through a
cap-independent internal ribosomal entry site (IRES)
How many species are there in the Enterovirus genus? - Answer 15
Name a couple of the important members of the Enterovirus genus - Answer
Enteroviruses A-L (which includes Poliovirus, vaccine preventable and causes
poliomyelitis, Enterovirus with multiple different serotypes, including simian, porcine
and bovine enteroviruses) and Rhinoviruses (A,B,C)
What is the receptor, host, and disease caused by Poliovirus? - Answer CD155, human
host, poliomyelitis; polio is also vaccine preventable
What is the receptor, host and disease caused by a Rhinovirus? - Answer LDLR/ICAM-1,
human, common cold
What is the receptor, host, and disease caused by foot-and-mouth disease virus? -
Answer Integrins, cloven-hoofed ungulates, and foot-and-mouth disease
What is the receptor,disease and host for Hepatitis A virus? - Answer HAVcr-1,
Hepatitis, and human; this is the only other vaccine preventable one
What is the distribution of Picornaviridae? - Answer Global, with some serotypes
preferring certain areas
What is the main reservoir of these viruses? - Answer Humans
How are these viruses mainly transmitted? - Answer Fecal-oral or respiratory
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