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Pharm II Final Exam 2024/2025
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Pharm II Final Exam Pharm II Final Exam Pharm II Final Exam
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Pharm II Final ExamPotassium - ANS What ion is a proton pump exchanging in order to secrete hydrogen ions into stomach
lumen?
Does not require active acid secretion - ANS What makes a potassium-competitive acid blocker (PCAB)
different from a PPI?
Omeprazole - ANS PPI that is commonly prescribed
PRN - ANS PPI are slow acting and do not work for _____ use
Mg and B12 - ANS What vitamins/minerals could be become deficient while taking a PPI?
Prodrug deactivation via CYP inhibition - ANS What DDI do PPIs have?
8 weeks - ANS PPIs have an 80% efficacy in improving Sx and mucosal healing after ____ weeks
PCAB - ANS MOA of vonoprazan
2-3 hrs; 12-24 hrs - ANS How fast does vonoprazan start working? How long does it last?
GERD and H. pylori - ANS What is the main use for vonoprazan?
H-2 Receptor Antagonist (H2RA) - ANS What med class is famotidine?
,Decreases acid secretion - ANS What is the MOA of H2RAs?
30 mins; 4-10hrs - ANS How fast do H2RAs work? How long do they last?
Decrease by 50% - ANS Pt needs famotidine but has CrCl<50. What should you do with the dosage?
Gynecomastia; CYP DDI - ANS Cimetidine can cause ____ in men and is most likely to have a ________
C. diff - ANS What risk do PPIs, PCABs, and H2RAs all have?
Constipation - ANS ADE of aluminum-containing antacids
Constipation - ANS ADE of calcium-containing antacids
Diarrhea - ANS ADE of magnesium-containing antacids
Hypernatremia - ANS ADE of sodium-containing antacids
Tetracyclines and FQs - ANS What meds can antacids decrease absorption of?
Sucralfate - ANS Med that binds (+) charged proteins and create a past-like barrier to treat GERD and
peptic ulcers
Constipation - ANS ADE of sucralfate
PPIs - ANS Most effective med class for GERD
,Studies were not definitive and do not establish cause/effect. Benefits far outweigh theoretical risk -
ANS You want to prescribe a Pt a PPI but they have concerns that long-term use can cause pneumonia,
stomach cancer, osteoporosis related bone fractures, chronic kidney disease, deficiencies of certain
vitamins and minerals, heart attacks, strokes, dementia and/or early death. What should you explain to
the Pt to put them at ease?
>2 weeks - ANS Pt is taking OTC PPI treatment for GERD. After what length of time should they see a
provider if Sxs persist?
PPI QD x 4-8 weeks - ANS 1st line treatment for mod-severe, persistent GERD
H2RA BID x 6-12 weeks - ANS 2nd line treatment for mod-severe, persistent GERD
Dysphagia, Wt loss >10%, anemia, bleeding, vomitinh - ANS What are the red flag Sxs to monitor when
treating GERD?
Antacid or Sucralfate - ANS What should med should you try first for pregnant women with GERD?
8-12 weeks - ANS If Pt is having extraesophageal Sxs, how long should they stay on PPI to treat GERD?
Refractory GERD - ANS GERD not responding to optimal treatment after 8 weeks
Nocturnal Acid Breakthrough - ANS What is a sign that a Pt has refractory GERD?
Relapse - ANS What can occur when stepping down in GERD treatment?
Duodenum - ANS Common location of H. pylori-caused ulcers
, Erosion - ANS GI damage that is superficial and does not extend through muscularis mucosa
Ulcer - ANS GI damage that extends through muscularis mucosa
Celebrex (COX-2 Selective) - ANS If Pt needs to take NSAID, which one would reduce risk for ulcers?
MI, stroke, GI bleeding - ANS Black box warnings for NSAIDs
Prostaglandins - ANS What do NSAIDs target to reduce inflammation but inhibit its GI protective
properties?
COX-1 - ANS What NSAID type affects GI lining?
PPI QD x 4 weeks + make NSAID changes - ANS Treatment for NSAID-induced peptic ulcers
Misprostol - ANS NSAID-Induced Peptic ulcer med that acts as a prostaglandin supplement
Explosive diarrhea - ANS Major ADE of misprostol
Abortion, premature birth, birth defects - ANS Black box warnings for misoprostol
Gram (-) rod - ANS Morphology of H. pylori
PPIs, Bismuth, ABX - ANS What meds can interfere with H. pylori diagnostics?
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