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MICN201 Jefka228's Chem Path (Lipoproteins) Exam
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MICN201 Jefka228's Chem Path (Lipoproteins) Exam...
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MICN201 Jefka228's Chem Path (Lipoproteins) ExamClear plasma appearance: - Answer No lipoprotein abnormality, increased HDL
Creamy layer, infranate clear or slightly turbid plama appearance: - Answer Increased
chylomicrons, Type I
Clear, possible increase in yellow-orange tint plasma appearance: - Answer Increased
LDL, Type IIa
Clear to slightly turbid plasma appearance: - Answer Increased LDL, VLDL, Type IIb
Turbid to opaque with thin 'cream' layer occasionally present plasma appearance: -
Answer Increased IDL and remnants, Type III
Turbid to opaque plasma appearance: - Answer Increased VLDL, Type IV
'Cream' layer, infranate turbid to opaque plasma appearance: - Answer Increased VLDL,
chylomicrons, Type V
Lipoprotein A: - Answer Cholesterol rich lipoprotein, modified form of LDL. Contributes
to atherosclerosis - adds to lipid accumulation in blood vessel wall, blocks activation of
plasmin by competing with plasminogen for binding fibrin and therefore interfering with
lysis of blood clots, stimulates smooth muscle cell proliferation
What happens to oxidised LDL in the blood? - Answer Oxidised LDL is rapidly taken up
by macrophages (scavenger receptor binds and internalises oxidised LDL) in artery
wall. Uptake of oxidised LDL by macrophages is an uncontrolled process - foam cells.
, 2 tissues that synthesize significant amounts of cholesterol in humans: - Answer Liver,
ileum
Major metabolic fates of cholesterol: - Answer Excretion into the gut, conversion to bile
acids
How does the body respond to increasing the amount of cholesterol in diet? - Answer It
decreases the rate of endogenous production of cholesterol
Absorption of cholesterol from food increased by: - Answer Fatty meal and bile salts
How are Chylomicrons synthesised? How are they broken down? - Answer Synthesized
by gut mucosa. Major lipid component is TAG (originates from diet). Broken down by
lipoprotein lipase which is activated by Apo CII and insulin
How are VLDL lipoproteins synthesised? - Answer Synthesized by liver. Major lipid
component TAG. Approximate ratio of cholesterol to TAG in these particles is 0.45
Insulin action that helps ensure fatty acids stored in adipose tissue after a meal: -
Answer Activation of lipoprotein lipase
Effect of low insulin on lipids as energy source: - Answer Release of insulin inhibition of
the hormone-sensitive lipase in adipose tissue cells
Differences between HSL and lipoprotein lipase: - Answer HSL - inside fat cells, acts on
intracellular TAG, inhibited by insulin, stimulated by adrenalin. LPL - in capillaries of
adipose tissue, acts on TAG of VLDL and chylomicrons, stimulated by insulin and
APOCII
Main function of LDL: - Answer Transport of cholesterol to peripheral tissues
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