Spadaro PCAM Final Material Questions
And Answers
What is an example of a pharmacokinetic interaction?
A) SAMe (S-adenosyl-methionine) increases serotonin levels, and combining it with a selective
serotonin reuptake inhibitor (SSRI) might cause serotonin syndrome
B) Flaxseed oil might decrease platelet aggregation and prolonged use of flaxseed with aspirin or
warfarin might increase the risk of bleeding
C) Taking large amounts of licorice increases potassium loss and combining it with a diuretic
may result in hypokalemia and hypotension
D) Orange juice inhibits organic anion transporting polypeptide (OATP) in the gut which might
decrease the absorption of fexofenadine D
Based on the system for evaluating the significance of drug-supplement interactions described in
this course, what would the overall rating be for an interaction that is "probable" and has
"moderate" severity?
A) Major
B) Moderate
C) Minor
, Spadaro PCAM Final Material Questions
And Answers
D) Insignificant B
What is the best way to prevent an interaction between grapefruit and CYP3A4 substrates?
A) Consume only white flesh grapefruit and avoid pink flesh
B) Separate consuming grapefruit and CYP3A4 substrate drugs by 4 hours
C)Avoid grapefruit juice , but it's okay to eat whole grapefruit
D) Avoid grapefruit and grapefruit products when taking CYP3A4 substrate drugs D
A transplant patient stabilized on cyclosporine mentions to his healthcare provider that he feels
depressed. He wants to try St. John's Wort. How would you counsel this patient?
A) Do not take St. John's wort
B) It's okay to take St. John's wort as long as cyclosporine levels are monitored
C) St. John's wort is a better choice than a conventional SSRI
D) St. John's wort does not interact with cyclosporine, it is okay to take A
, Spadaro PCAM Final Material Questions
And Answers
A 32-year-old female asks you if she should take an allicin-rich garlic supplement for lower
cholesterol. Her current medications include an oral contraceptive, ibuprofen as needed for
menstrual discomfort, and calcium. What would you recommend for this patient?
A) She should separate administration of ibuprofen and garlic by at least 2 hours
B) Don't use calcium and garlic at the same time because it can decrease the effectiveness of
garlic
C) Use a backup form of birth control while taking allicin-rich garlic
D) Garlic may cause severe stomach discomfort when taken with an oral contraceptive C
A patient was prescribed ciprofloxacin for a lower respiratory tract infection. She has heard that
some people drink tea and honey to battle similar infections. She doesn't like drinking tea but she
is planning to start taking green tea capsules instead. How would you counsel this patient?
A) It's okay to take the green tea supplement
B) Do not take the green tea supplement, but it's okay to drink green tea
C) Do not take the green tea supplement, and do not drink green tea while taking ciprofloxacin
D) Take the green tea supplement, but separate it from the ciprofloxacin by 2 hours C
, Spadaro PCAM Final Material Questions
And Answers
Which is a clinically significant drug-supplement interaction?
A) Calcium and clopidogrel
B) Fish oil and aspirin
C) Ginkgo and diazepam
D) St. John's wort and cyclosporine D
An overweight patient with diabetes is interested in trying the supplement garcinia to help him
lose weight. He currently takes aspirin, glyburide, citalopram, simvastatin, and benazepril.
Which combination might result in a significant interaction?
A) Garcinia <> benazepril
B) Garcinia <> citalopram
C) Garcinia <> glyburide
D) Garcinia <> simvastatin B
A 72-year-old female recently had a percutaneous intervention (PCI) and is taking aspirin and
clopidogrel in addition to other medications. She wants to buy a supplement containing ginkgo,
And Answers
What is an example of a pharmacokinetic interaction?
A) SAMe (S-adenosyl-methionine) increases serotonin levels, and combining it with a selective
serotonin reuptake inhibitor (SSRI) might cause serotonin syndrome
B) Flaxseed oil might decrease platelet aggregation and prolonged use of flaxseed with aspirin or
warfarin might increase the risk of bleeding
C) Taking large amounts of licorice increases potassium loss and combining it with a diuretic
may result in hypokalemia and hypotension
D) Orange juice inhibits organic anion transporting polypeptide (OATP) in the gut which might
decrease the absorption of fexofenadine D
Based on the system for evaluating the significance of drug-supplement interactions described in
this course, what would the overall rating be for an interaction that is "probable" and has
"moderate" severity?
A) Major
B) Moderate
C) Minor
, Spadaro PCAM Final Material Questions
And Answers
D) Insignificant B
What is the best way to prevent an interaction between grapefruit and CYP3A4 substrates?
A) Consume only white flesh grapefruit and avoid pink flesh
B) Separate consuming grapefruit and CYP3A4 substrate drugs by 4 hours
C)Avoid grapefruit juice , but it's okay to eat whole grapefruit
D) Avoid grapefruit and grapefruit products when taking CYP3A4 substrate drugs D
A transplant patient stabilized on cyclosporine mentions to his healthcare provider that he feels
depressed. He wants to try St. John's Wort. How would you counsel this patient?
A) Do not take St. John's wort
B) It's okay to take St. John's wort as long as cyclosporine levels are monitored
C) St. John's wort is a better choice than a conventional SSRI
D) St. John's wort does not interact with cyclosporine, it is okay to take A
, Spadaro PCAM Final Material Questions
And Answers
A 32-year-old female asks you if she should take an allicin-rich garlic supplement for lower
cholesterol. Her current medications include an oral contraceptive, ibuprofen as needed for
menstrual discomfort, and calcium. What would you recommend for this patient?
A) She should separate administration of ibuprofen and garlic by at least 2 hours
B) Don't use calcium and garlic at the same time because it can decrease the effectiveness of
garlic
C) Use a backup form of birth control while taking allicin-rich garlic
D) Garlic may cause severe stomach discomfort when taken with an oral contraceptive C
A patient was prescribed ciprofloxacin for a lower respiratory tract infection. She has heard that
some people drink tea and honey to battle similar infections. She doesn't like drinking tea but she
is planning to start taking green tea capsules instead. How would you counsel this patient?
A) It's okay to take the green tea supplement
B) Do not take the green tea supplement, but it's okay to drink green tea
C) Do not take the green tea supplement, and do not drink green tea while taking ciprofloxacin
D) Take the green tea supplement, but separate it from the ciprofloxacin by 2 hours C
, Spadaro PCAM Final Material Questions
And Answers
Which is a clinically significant drug-supplement interaction?
A) Calcium and clopidogrel
B) Fish oil and aspirin
C) Ginkgo and diazepam
D) St. John's wort and cyclosporine D
An overweight patient with diabetes is interested in trying the supplement garcinia to help him
lose weight. He currently takes aspirin, glyburide, citalopram, simvastatin, and benazepril.
Which combination might result in a significant interaction?
A) Garcinia <> benazepril
B) Garcinia <> citalopram
C) Garcinia <> glyburide
D) Garcinia <> simvastatin B
A 72-year-old female recently had a percutaneous intervention (PCI) and is taking aspirin and
clopidogrel in addition to other medications. She wants to buy a supplement containing ginkgo,
