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D&T methodieken KERNGENEESKUNDE samenvatting $6.96   Add to cart

Summary

D&T methodieken KERNGENEESKUNDE samenvatting

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Samenvatting van de cursus (geen ppt's) van kerngeneeskunde (nucleaire geneeskunde), deel van diagnostische en therapeutische methodieken

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  • February 3, 2020
  • 10
  • 2019/2020
  • Summary
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NUCLEAIRE GENEESKUNDE
1. DE SPECIALITEIT

1.1. INLEIDING

Combinatie: beeldvorming en behandeling
Per indicatie juiste farmacon kiezen, doseren en toepassen

1.2. DEFINITIE

Maakt gebruik van open radioactieve bronnen: patiënt wordt bron
- 90% diagnostiek
- 10% therapie
Farmacon gemerkt met radioactieve stof (isotoop) toedienen
=> verdeling, wordt opgenomen op plaatsen waar bepaald fysiologisch proces
afspeelt
=> radioactief verval van isotoop
=> (gamma)stralen
=> detectie van stralen
=> bepaling biodistributie van radiofarmacon in lichaam
Radiofarmacon = combinatie speurstof voor specifiek orgaan/orgaansysteem en
radioactief isotoop om proces in beeld te brengen
Diagnostische nucleaire geneeskunde: SPECT en PET
- SPECT = single photon emission computed tomography: maakt gebruik van
radionucliden die enkele gammastralen uitzenden
- PET = positron emission tomography: maakt gebruik van positron emitters die
dubbele gammastralen uitsturen
- Positron emitters = vaak radioactieve varianten van biologisch atoom, geïncorporeerd
in speurstof
- Single photon emitters = radioactieve merking via linkers die radionucleotide
koppelen aan speurstof
Radionuclidentherapie: speurstof gekoppeld aan therapeutisch radionuclide (alfa of
beta straal: hogere energie)
=> geeft grote hoeveelheid energie af op korte afstand
=> DNA-beschadiging en vernietiging van tumorcel door ds DNA-breuken


2. CONVENTIONELE NUCLEAIRE GENEESKUNDE
Zie tabel


3. PET-BEELDVORMING
Zie tabel


4. THERAPIE
Zie tabel

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