NBME Practice (Anatomy, Embryo, Physio,
Biochem, Histo) Questions and Answers
100% Pass
A hormone is known to activate phospholipase C with subsequent release of calcium from
internal stores. The release of
calcium most likely occurs as a result of an increase in the concentration of which of the
following intracellular second
messengers?
(A) Calcium
(B) cAMP
(C) cGMP
(D) Diacylglycerol
(E) Inositol 1,4,5-trisphosphate - answer✔(E) Inositol 1,4,5-trisphosphate
A 28-year-old man with a history of intravenous drug use comes to the physician because of a 6-
week history of fever,
nonproductive cough, chills, and progressive shortness of breath. His temperature is 39°C
(102.2°F), pulse is 110/min,
respirations are 32/min and regular, and blood pressure is 120/80 mm Hg. Physical examination
shows a white, patchy,
loosely adherent exudate on the buccal mucosa bilaterally. A chest x-ray shows bilateral
interstitial infiltrates. After
receiving treatment for pneumonia, he agrees to participate in a clinical study of the effects of
interleukin-2 (IL-2). After
administration of IL-2, which of the following hematologic changes is most likely in this patient?
(A) Decreased CD4+ T lymphocytes
(B) Decreased erythrocytes
(C) Decreased platelet count
(D) Increased CD4+ T lymphocytes
(E) Increased erythrocytes
(F) Increased platelet count - answer✔(D) Increased CD4+ T lymphocytes
A 5-year-old girl falls through the ice while skating on an outdoor pond. She is removed from the
water within 1 minute,
but dry clothing is not available, and she is still cold and wet 20 minutes later. Which of the
following mechanisms helps
maintain the patient's core temperature during the period following her rescue?
(A) Cutaneous vasodilation
(B) Diving response
(C) Increased thermoregulatory set point
(D) Release of endogenous pyrogen
(E) Shivering - answer✔(E) Shivering
A 39-year-old woman comes to the physician for a follow-up examination because she recently
was diagnosed with
hypertension. Her blood pressure is 156/100 mm Hg. Physical examination shows no other
abnormalities. Serum studies
show normal findings. A 24-hour urine collection shows three times the normal excretion of
epinephrine and
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