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Na+_K+ - ATPase
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Na+/K+ - ATPase Q&Athe Na/K ATPase pump does what in cells - (correct answer)1. osmotic balance
2. establish excitability
ATPase - (correct answer)enzyme; job is to break off the terminal phosphate (takes a lot
of energy to do this)
takes ATP and breaks it down into ADP + phosphate + ENERGY (where most of the
energy comes from during co-transport)
most common active transport mechanism in the cell - (correct answer)sodium
potassium ATPase; active in all cells
why do we have to have a pump that gets rid of sodium in the cells? - (correct
answer)cells maintain an osmotic balance. most sodium should stay outside of the cell.
over time, sodium via diffusion goes into the cell, and water follows it.
what's the ratio of ions in the sodium potassium ATPase pump - (correct answer)3
sodiums pumped out and 2 potassiums pumped in
what does the term electrogenic pump mean? - (correct answer)in a cell, if you have
pump going all the time, pumping out 3 positive things and bringing in 2 positive things,
automatically creates an electrical potential difference between outside and inside of the
cell
Outside is more positive than the inside; what he means by electrogenic pump
Na+/K+ ATPase is what kind of transport - (correct answer)active transport
, Na+/K+ ATPase mechanism - (correct answer)The pump, with ATP bound, binds 3
intracellular Na+ ions
ATP is hydrolyzed, leading to phosphorylation of the pump at an aspartate residue with
the subsequent release of ADP
A conformational change in the pump exposes the Na+ to the outside for release
the Na+/K+ ATPase pump binds 2 K+ ions, leading to - (correct
answer)dephosphorylation of the pump.
ATP binds and the pump reorients to release K+ inside the cell.
repeat action
the pump in the heart cells is a target of the - (correct answer)cardiac glycosides
digoxin and ouabain increase ___. how? - (correct answer)force of contraction
The influx of calcium causes contraction and is then carrier back out by a carrier
enzyme in the sarcolemma...causing relaxation
This carrier enzyme uses the Na+ gradient generated by the Na-K pump to remove the
Ca++ from the inside
Thus, slowing down the Na+-K+ pump results in a permanently higher Ca++ level inside
the cell, resulting in stronger contractions
what 2 poisons can destroy the Na/K ATPase pump - (correct answer)ouabain and
digitalis
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