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MICB 212 Chap 1-6, 8-10 Exam Practice Questions and Answers $11.49
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MICB 212 Chap 1-6, 8-10 Exam Practice Questions and Answers
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MICB 212 Chap 1-6, 8-10 Exam Practice Questions and Answers Which leukocytes are derived from myeloid precursors? - ANSWERMonocytes/macrophages, neutrophils, eosinophils, basophils, mast cells, and some types of dendritic cells. Where are HSCs found in the body? What problems would a person hav...

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  • October 30, 2024
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FIRST PUBLISH OCTOBER 2024




MICB 212 Chap 1-6, 8-10 Exam Practice

Questions and Answers


Which leukocytes are derived from myeloid precursors? - ANSWER✔✔Monocytes/macrophages,

neutrophils, eosinophils, basophils, mast cells, and some types of dendritic cells.


Where are HSCs found in the body? What problems would a person have if they didn't have HSCs? -

ANSWER✔✔bone marrow, blood, umbilical cord blood


What are the differences between the primary and secondary lymphoid organs? - ANSWER✔✔primary -

cells develop, secondary - immune responses develop


You surgically remove the thymus from both a newborn mouse and an adult mouse. What effects would

this have on the newborn mouse, and what effects would this have on the adult mouse? Explain the

differences or similarities. - ANSWER✔✔no mature T cells -> no cell mediated or humoral responses

against pathogen (child is when most T cells mature)


What are some examples of barriers in our bodies, and how do barriers function to exclude invading

microbes? - ANSWER✔✔Epithelial layers - intact skin. Internal epithelial layers - layer of mucus ->

prohibit pathogens from squeezing into the tissues, traps pathogens inhibiting their ability to adhere to

host tissues.

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What molecules do phagocytes use to identify an invading microbe versus a host cell? -

ANSWER✔✔PAMPS pathogen associated molecular patterns -> peptidoglycan (PG), lipopolysaccharide

(LPS), double-stranded RNA.


What are the functions of cell-membrane associated Pattern Recognition Receptors (PRRs)? -

ANSWER✔✔receptors on cells of the innate immune that recognize PAMPs (essential to the pathogen

and therefore, do not undergo frequent mutation), can be involved in phagocytosis and signalling

pathways (transcription of genes)


Person A was born with a genetic defect that results in an inability to produce complement component

C3. Person B was born with a different genetic defect and is unable to produce complement component

C5. Who would have a more difficulty in eliminating a bacterial infection? Why? - ANSWER✔✔A because

C3 is required in early complement (no opsonization or MAC) but B will have opsonin C3b


How would a macrophage or neutrophil identify an invading bacterium from some innocuous debris? -

ANSWER✔✔TLRs recognize PAMPs


What are the products made by the cell when the transcription factor NF-κB has been activated? -

ANSWER✔✔cytokines: IL-1, IL-6, TNF alpha


chemokines: IL-8 (CXCL8)


for DC: homing receptors




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