CHEM 310 Exam 1 || Questions and 100% Verified Answers.
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Course
CHEM 310
Institution
CHEM 310
Pharmaceutical market is forecast to grow to about $_____ in 2012:
A) $1 billion
B) $10 Million
C) $50 Million
D) $1 Trillion
E) $500 Million correct answers D) $1 Trillion
QSAR is an abbreviation for:
A) Quantity Structure Analysis for Receptors
B) Qualitative Structure Analysis b...
CHEM 310 Exam 1 || Questions and 100% Verified Answers.
Pharmaceutical market is forecast to grow to about $_____ in 2012:
A) $1 billion
B) $10 Million
C) $50 Million
D) $1 Trillion
E) $500 Million correct answers D) $1 Trillion
QSAR is an abbreviation for:
A) Quantity Structure Analysis for Receptors
B) Qualitative Structure Analysis by Researchers
C) Quantity Structure Analysis Reasoning
D) None of the above.
E) Quantitative Structure-Activity Relationships correct answers E) Quantitative Structure-
Activity Relationships
Grimm's Hydride Displacement Law states that a CH2 can be replaced with an NH2 in a
molecule without a change in structure: TRUE FALSE correct answers FALSE
ADME is an abbreviation for:
A) absorption, metabolism, distribution, excretion
B) abrogation, metastasis, distribution, excretion
C) absorption, metabolism, distribution, evaluation
D) absorption, metabolites, distribution, excretion
E) absorption, medicinal, distance, evaluation correct answers A) absorption, metabolism,
distribution, excretion
Proteins are made from information stored in the genes: TRUE FALSE correct answers TRUE
What is the most logical and molecular approach to drug discovery?
A) Synthetic and Biophysical Organic Chemistry.
B) Structure Based Drug Design.
C) QSAR.
D) High Throughput Screening (finding a needle in a hay stack).
E) Isosteric Replacement. correct answers B) Structure Based Drug Design.
Biological activity
a. is not related to molecular structure
b. can not be estimated
c. may be modeled mathematically
d. is not related to physical properties correct answers c. may be modeled mathematically
Biological activity is postulated to begin with
a. a large pharmacophore
b. a large receptor
, c. a pharmacophore-receptor encounter
d. a QSAR model correct answers c. a pharmacophore-receptor encounter
The receptor is
a. a feature on the drug molecule
b. the entire drug molecule
c. the measure biological response
d. part of a macromolecule in the body correct answers d. part of a macromolecule in the body
The pharmacophore is
a. part of the drug molecule
b. the entire drug molecule
c. the measure of drug activity
d. a measure of biological response correct answers a. part of the drug molecule
The biophase is
a. the liver
b. the region of drug-receptor encounter
c. the outcome of QSAR
d. the region of excretion correct answers b. the region of drug-receptor encounter
QSAR is
a. a synthetic method
b. dependent upon crystal studies
c. a modeling method
d. an experimental method correct answers c. a modeling method
The Hansch model relates
a. activity and physical properties
b. activity and the pharmacophore
c. the pharmacophore and the receptor
d. the pharmacophore and the receptor correct answers a. activity and physical properties
Important pharmacokinetics parameters are:
a. Administration (A) and dispensing (D)
b. Clearance (CL) and volume of distribution (V)
c. Formulation (F) and half-time (t½)
d. All of the above correct answers b. Clearance (CL) and volume of distribution (V)
Drug concentrations in plasma following intravenous bolus administration of 100 mg of the drug
as a function of time can be described by the equation: C = 10mg/L e-0.17t). The half-life of this
drug is:
a. 1 hour
b. 2 hours
c. 3 hours
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