10/31/24, 5:54 AM 2024 update |NRNP 6566 WK1-5 Midterm|2024-2025 latest|COMPREHENSIVE QUESTIONS AND VERIFIED ANSWERS (1…
2024 update |NRNP 6566 WK1-5 Midterm|2024-
2025 latest|COMPREHENSIVE QUESTIONS AND
VERIFIED ANSWERS (100% Correct solutions)
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Terms in this set (36)
Describe cytochrome Cytochrome p450 system is a series of enzymes
p450 system used to metabolize medications
block metabolic activity from one or more CYP450
Inhibitors
enzymes
increase CYP450 enzyme activity by increasing
Inducers
enzyme synthesis
Albumin is the plasma protein with the greatest
Describe effect on low capacity for binding drugs. Binding plasma proteins
and high albumin levels affect drug distribution into tissues, because only
on active drug levels drug that is not bound is available to penetrate
especially for drugs that tissues, bind to receptors, and exert activity. As free
are highly protein bound drug leaves the blood stream, more bound drug is
released from binding sites.
Low albumin levels malnutrition, chronic illness
toxicity in patients with low albumin levels, example
Highly protein bound
malnutrition or chronic illness. This is because there
drugs can lead to
are fewer than the normal sites for the drug to bind
, 10/31/24, 5:54 AM 2024 update |NRNP 6566 WK1-5 Midterm|2024-2025 latest|COMPREHENSIVE QUESTIONS AND VERIFIED ANSWERS (1…
Alternative routes include:
suppository
intravenous
Describe the ways the
intramuscular
hepatic first pass effect-
inhalational aerosol
which is metabolism
transdermal
during first pass through
sublingual
the liver
These allow drugs to bypass the first-pass effect
and be absorbed directly into systemic circulation
Be able to calculate Male = 140-age times weight in kilograms divided by
creatinine clearance serum creatinine times 72.
using Cockgraft Gault Women = CRCL (male) times 0.85
equation:
Describe what half life
determines the frequency plasma concentration
of drug administration
Potentially Inappropriate Medication Use in Older
Adults
Be familiar with the beers
to call attention to medications that are most
criteria and how to use it
commonly problematic and thus should be avoided
in older adults
low blood state (shock or arrest), contact time with
GI tract too fast (diarrhea = cant absorb), delayed
Describe factors that
stomach emptying (large meal = delayed
affect absorption
absorption)Drug- to drug or drug to food
interactions
Describe the factors that low albumin levels, body composition, cardiac
affect distribution decompensation (heart failure), age
Describe the factors that genetics, age, organ function
affect metabolism
Describe factors that affected by abnormal kidney or liver function, age,
affect excretion drug interactions
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