USMLE Step 1 - uWorld High Yield Notes Exam Study Questions and Answers
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Course
USMLE
Institution
USMLE
USMLE Step 1 - uWorld High Yield Notes
Exam Study Questions and Answers
What are the two major microtubular motor proteins? Which does anterograde axonal transport, which
does retrograde axonal transport? - ANSWER-Kinesin, Dynein
Kinesin: Anterograde
Dynein: Retrograde`
What do you think, imm...
Which microtubule associated protein aids in anterograde transport of intracellular vesicles and
organelles? Which end of the microtubule do they go towards? - ANSWER✔✔-Kinesin.
Towards the (+) rapidly growing end.
What is an early BRAIN finding of Ataxia-Telangiectasia and how does it manifest itself? - ANSWER✔✔-
Cerebellar atrophy
manifests as ataxia in the first years of life.
High yield path association for Alzheimer's disease? - ANSWER✔✔-Neurofibrillary tangles in the
neocortex
High yield path association for Parkinson's disease? - ANSWER✔✔-Loss of neurons in the substantia
nigra
High yield path association for Huntington disease? - ANSWER✔✔-Atrophy of caudate nucleus
What are the major manifestations of Ataxia-telangiectasia? - ANSWER✔✔-cerebellar ataxia,
oculocutaneous tenlangiectasias, repeated sinopulmonary infections, and an increased incidence of
malignancy
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