, 1. Which CYP450 enzyme is primarily responsible for the
metabolism of warfarin, and how does it affect dosing?
- A) CYP2D6
- B) CYP2A6
- C) CYP3A4
- D) CYP2C9
- Answer: D) CYP2C9
- Rationale: Warfarin is mainly metabolized by CYP2C9,
and variations in this enzyme can significantly affect drug
clearance and necessitate dosage adjustments.
2. In treating hypertension, ACE inhibitors are often
prescribed. What is the primary mechanism by which these
drugs lower blood pressure?
- A) Reducing heart rate
- B) Blocking angiotensin II formation
- C) Increasing sodium retention
- D) Enhancing vasoconstriction
- Answer: B) Blocking angiotensin II formation
- Rationale: ACE inhibitors prevent the conversion of
angiotensin I to angiotensin II, leading to vasodilation and
decreased blood pressure.
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