What are Examples of Peripherally Acting Muscle Relaxants? - ANSWER
Dantrolene
What are Examples of Centrally Acting Muscle Relaxants? - ANSWER
>Baclofen
>Cyclobenzaprine
>Tizanidine
>Diazepam
What is the Mechanism of Action of Peripherally Acting Muscle Relaxants?
Route of Administration? - ANSWER Work directly on muscle fibers
>Inhibits muscle contraction by blocking release of Ca+ in skeletal muscle
>Given IV
What are the Uses of Peripherally Acting Muscle Relaxants? - ANSWER >CP
>MS
>Spinal cord injury
>Malignant hyperthermia
What are Complications of Peripherally Acting Muscle Relaxants? - ANSWER
>N&V
,>Abdominal pain
>Jaundice
>Hepatotoxicity
>Muscle weakness
How to Evaluate Effectiveness of Peripherally Acting Muscle Relaxants? -
ANSWER Absence of muscle rigidity
What is the Mechanism of Action of Diazepam? - ANSWER Mimic actions of
GABA at receptors in the spinal cord and brain to produce sedative effects
and depress spasticity of muscles
What are the Uses of Diazepam? - ANSWER >Muscle spasm
>More likely for seizures, anxiety and panic, ETOH withdrawal, and for
anesthesia induction
What are Side Effects of Diazepam? - ANSWER >Heavy sedation
>N&V
>Jaundice
>Hepatotoxicity
What are Patient Education Tips for Diazepam? - ANSWER Do not stop
, medication abruptly--taper
How to Evaluate Effectiveness of Diazepam? - ANSWER Improvement of the
condition medication used to treat
What is the Mechanism of Action of Cyclobenzaprine and Tyzanidine? -
ANSWER Enhance GABA at brain and spinal cord receptors to produce
sedation and depress spasticity of muscles. Do not decrease muscle strength
What are the Uses of Cyclobenzaprine and Tyzanidine? - ANSWER Relief of
muscle spasm r/t injury
What are Side Effects of Cyclobenzaprine and Tyzanidine? - ANSWER
>Anticholinergic effects
>May cause cardiac dysrhythmias
How to Evaluate Effectiveness of Cyclobenzaprine and Tyzanidine? - ANSWER
Improved ROM and decreased pain
What is the Mechanism of Action of Baclofen? - ANSWER Enhances GABA in
the CNs to produce sedative effects and depress spasticity of muscles. Does
not produce muscle weakness
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