Exam (elaborations)
Dosage Forms Exam 3 - MCPHS 2024/2025: Qs And As
- Course
- Institution
Dosage Forms Exam 3 - MCPHS 2024/2025: Qs And As
[Show more]
Content preview
Dosage Forms Exam 3 - MCPHS 2024/2025: Qs And AsPharmaceutics Right Ans - General area of study concerned with the
formulation, manufacture, stability and effectiveness of pharmaceutical
dosage forms
Drug Right Ans - any agent intended for use in the diagnosis, mitigation,
treatment, cure or prevention of disease in humans or other animals
Active Pharmaceutical Ingredient Right Ans - Any component that is
intended to cause pharmacologic activity or other direct drug effects
Broad steps of new drug development Right Ans - 1) Drug Discovery
2) Animal Studies
3) Clinical Tests
4) Commercialization
In silico screening Right Ans - Biological experimentation performed by a
computer
Drug discovery methods Right Ans - 1) Screening natural compounds
2) Screening corporate compounds
3) In silico screening
4) Rational drug design
5) Combinatorial chemistry
Combinatorial Chemistry Right Ans - Preparation of a large number of
different compounds at the same time
ADMET Right Ans - Absorption
Distribution
Metabolism
Excretion
Toxicity
Absorption (testing) Right Ans - To see that the drug passes GI track into
blood stream
, Distribution (testing) Right Ans - To see that the the drug gets to target
tissue
Metabolism (testing) Right Ans - To see that the drug is not readily
metabolized
Excretion (testing) Right Ans - To see that the drug is not readily secreted
Toxicity (testing) Right Ans - To see that the drug is not toxic to other cells
or tissue
Biologic Pre-clinical Tests Right Ans - Pharmacology, Drug metabolism and
toxicology experiments
Preformulation Studies Right Ans - 1) Drug solubility
2) Partition coefficient
3) Dissolution rate
4) Physical form
5) Stability
Clinical Phase I Right Ans - Study's absorption/metabolism, effects on
organs and tissue and side effects on ~20-100 healthy volunteers
IND Right Ans - Investigational New Drug Application
Clinical Phase II Right Ans - Studies effectiveness in treatment, short-term
side effects and dose range on a large number of patients (control and
treatment groups)
Clinical Phase III Right Ans - Studies benefit/risk relationship of drug, less
common/longer term side effects, and labeling information on a very large
group of patients
NDA Right Ans - New Drug Application
Reasons for new drug failure Right Ans - Pharmacokinetics (39%)
Lack of efficacy (30%)
Animal toxicity (11%)
Adverse effects in man (10%)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LeCrae. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
85169 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now