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OST 575 Exam-Liver Functions |Questions with 100% Correct Answers
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OST 575 Exam-Liver Functions |Questions with 100% Correct Answers
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OST 575 Exam-Liver Functions|Questions with 100% Correct Answers
What does Prothrombin time (PT) measure? - ✔ ✔ how long it takes plasma
sample to clot after a mixture of *thromboplastin (factor III)* and *calcium ions*
are added
Activated partial thromboplastin time (aPTT) measures what? - ✔ ✔ time it takes
a plasma sample to clot from the activation of *Factor XII (top of intrinsic
pathway)*
What are the players that can be tested to assess liver function?
- ✔ ✔ aminotransferases
serum proteins (ALBUMIN)
Bilirubins
Blood clotting factors
alkaline phosphatase and gamma-glutamyl transpeptidase
What is the function of an aminotransferase enzyme in the liver? - ✔ ✔ catalyzes
the transfer of NH2 group from a *donor alpha amino acid* to an *acceptor KETO
ACID*
What is the reason for having aminotransferase enzymes in the liver? - ✔ ✔
can make a particular amino acid needed by a cell
, can get rid of a particular amino acid by transferring the NH2 to alpha-
ketoglutarate (*done for urea extretion*)
Are the aminotransferase enzymes in the liver EXTRAcellular or INTRAcellular? -
✔ ✔ INTRACELLULAR
Why is it important to know that aminotransferase enzymes in the liver are found
intracellular and NOT in the plasma? - ✔ ✔ Elevated plasma levels of
aminotransferases usually indicate *damage to tissues* rich in these enzymes
What are the two specific aminotransferase liver enzymes usually measured? -
✔ ✔ AST
ALT
Which liver aminotransferase, AST or ALT, is more specific for liver disease?
Which is easier to detect? - ✔ ✔ *ALT* --> liver disease specific
AST --> easier to detect
What can cause plasma levels of aminotransferases to be elevated? -
✔ ✔ Myocardial infarction
muscle disorders
What is albumin secreted by? - ✔ ✔ Liver
What does albumin transport? - ✔ ✔ free fatty acids
bile acids (derived from cholesterol)
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