cadherin ANS✔✔ A calcium-dependent adherence protein, important in the
adhesion of cells to other cells, homophilic specificity, bidirectional signaling
bidirectional signaling ANS✔✔ -Involves both anterograde signaling by the
axon and retrograde signaling by the dendrite.
-Important for the development of early neuronal circuits that mediate the
most basic functions of a given cortical area
beta-catenin ANS✔✔ links the intracellular domain of the cadherin receptor
to actin filaments inside cell to anchor the synapse, in short supplies so only
the strong get to use and weak are pruned
cadherin-beta-catenin complex ANS✔✔ needed for pruning of dendritic
spines, helps to stabilize cadherins to actin
changes with age ANS✔✔ number of dendritic spines or cortical neurons
fragile x syndrome ANS✔✔ ineffective synapses aren't pruned away,
extended repeats leads to extra scaffolding, overabundance of synapses
and lack of competition
scaffolding protein ANS✔✔ A type of large relay protein to which several
other relay proteins are simultaneously attached, increasing the efficiency
of signal transduction.
, Solution 2024/2025
Pepper
snare complex ANS✔✔ set of proteins that allow the vesicle to attach to the
plasma membrane
neurexin ANS✔✔ presynaptic membrane, binds to neuroligin in the
postsynaptic membrane, promoting adhesion, and helps localize synaptic
vesicles, docking proteins, and fusion molecules, recruits scaffolding
proteins to set up for exocytosis
neuroligin ANS✔✔ Postsynaptic binding partner of the presynaptic adhesion
molecule neurexin. Promotes the clustering of receptors and channels of the
postsynaptic density as the synapse matures.
myoblasts ANS✔✔ stem cells that fuse to form each muscle fiber
myotubes ANS✔✔ Fused myoblasts, whwere actin and myosin are
organizing
aggregation of AChRs at muscle ANS✔✔ growth cone attaches to myotubes
to facilitate maturation into muscle fibers, AChR concentrated at tops of
junctional folds (by terminal)
basal lamina sheath ANS✔✔ formed between the axon and muscle, layers of
ECM
migrating muscle growth cone ANS✔✔ already coming to target with its
ability to release ACh
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