What are the 3 main sites of extramedullary hematopoiesis in order of prominence? - ANSWER Spleen, Liver, Lymph nodes
Grossly, bone marrow is either red or yellow. What does each represent? - ANSWER Red - hematopoietic tissue
Yellow - adipose tissue
What are the 3 main sites of extramedullary hematopoiesis in order of prominence? - ANSWER Spleen,
Liver, Lymph nodes
Grossly, bone marrow is either red or yellow. What does each represent? - ANSWER Red - hematopoietic
tissue
Yellow - adipose tissue
What percentage of marrow cellularity in adult dogs is comprised of morphologically indistinct
hematopoietic precursors? - ANSWER less than 2%
What 3 stem cell types can a pluripotent hematopoietic stem cell (HSC) become upon cell division? -
ANSWER lymphoid stem cell, GEMM stem cell, Itself (HSC)
what is the name of the earliest erythroid precursor that can be identified morphologically by light
microscopy? - ANSWER Rubriblast
Regarding O2 sensing and initiation of erythropoiesis:
A. what is the oxygen-sensing protein of tissues
B. how do tissue oxygen levels regulate its funcion
C. with tissue hypoxia, this protein stimulates production of what key hormone of erythropoiesis
D. this key hormone is produced primarily in which organ? - ANSWER A: Hypoxia Inducible Factor's
(HIF's)
B: If O2 is sufficient - HIF's are hydroxylated (-OH) and destroyed
If O2 is insufficient - HIF's are not hydroxylated and form heterodimers that will stimulate the production
of EPO
C: Erythropoietin (EPO)
D: Kindey
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