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NSCI 4501 Exam 1 Questions & Answers 2024/2025 $9.49   Add to cart

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NSCI 4501 Exam 1 Questions & Answers 2024/2025

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NSCI 4501 Exam 1 Questions & Answers 2024/2025 Extrasynaptic NMDA R - ANSWERSchronic activity leads to excitotoxicity and cell death signalling Synaptic NMDA R - ANSWERSchronic activity leads to neuroprotection VSCC - ANSWERScalcium channel, allows Ca into cell, upregulated by AMPAR acti...

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  • November 1, 2024
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  • 2024/2025
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  • NSCI 4501
  • NSCI 4501
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NSCI 4501 Exam 1 Questions & Answers
2024/2025

Extrasynaptic NMDA R - ANSWERSchronic activity leads to excitotoxicity and cell death signalling



Synaptic NMDA R - ANSWERSchronic activity leads to neuroprotection



VSCC - ANSWERScalcium channel, allows Ca into cell, upregulated by AMPAR activation



NMDAR - ANSWERSactivated by glu and depolarization; allows calcium into cell; important for synaptic
plasticity



AMPA R - ANSWERSactivated by glutamate; upregulates NMDAR and VSCC activity -->more calcium



mGluR - ANSWERSmetabotropic glutamate receptor; activated by glutamate; activates PLC



PLC - ANSWERSactivated by mGluR; converts PIP2 to IP3



PIP2 - ANSWERSconverted to IP3 by PLC



IP3 - ANSWERSactivates IP3R on ER membrane; leads to calcium release/excitotoxicity



IP3R - ANSWERSER membrane receptor for IP3 ligand; releases calcium from ER; increases excitotoxicity
activity



3 stages of excitotoxicity - ANSWERS1. Initiation

2. Amplification

3. Expression

, 3 key molecules of apoptosis - ANSWERS1. Bcl-2 family proteins

2. Apaf-1

3. caspases



3 groups of Bcl-2 family proteins - ANSWERS1. Group I - Anti-apoptitic

2. Group II - Inducers

3. Group III - Potentiate



Anti-apoptitic (Group I) Bcl-2 members - ANSWERSBcl-2; Bcl-xl



Inducing (Group II) Bcl-2 members - ANSWERSBax



Potentiating (Group III) Bcl-2 members - ANSWERSBad, Bid, Bik



Bcl-2 members can act as... - ANSWERSCyt. c channels, caspase activators, or ion channels (all at
mitochondrial outer membrane)



caspase - ANSWERScysteine-aspartate protease; cleave proteins that contain aspartic acid; 2 subunits
(large and small)



zymogen - ANSWERScatalytically inactive proenzyme



Caspase Prodomain Classification - ANSWERS1. DED

2. CARD



DED (Death Effector Domain) caspases - ANSWERS8, 10



CARD (caspase-activating recruitment domain) caspases - ANSWERS1, 2, 4, 5, 9

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