Resting membrane potential ANS✔✔ membrane potential determined by: Relative permeability of
the membrane, and concentration gradients of the ions
concentration gradient fairly constant: Action of Na+K+ATPase
permeability determined by: type/number of channels, leak channels, K+ channels (and many
more)
effects on membrane potential ANS✔✔ Effect of Na+K+ pump->
,2024/2025
3 Na+ to 2 K+,charge imbalance / negative inside->
but mostly creates gradient..->
Effects of Potassium Diffusion->
Concentration gradient moves K+ out ->
Charge opposes movement out
*a very small number of ions creates large charge difference
The Nernst Equation ANS✔✔
Excitable tissues ANS✔✔ nerve and muscle
developed specialized use for potential membrane
able to undergo rapid transient changes in potential
Signals to receive, process, initiate, and transmit message
Signals to initiate contractile apparatus
graded potentials ANS✔✔ short distance signals
action potentials ANS✔✔ long distance signals
, 2024/2025
membrane triggering events ANS✔✔ stimulus
chemical ligand
electrical field
spontaneous
stimulus ANS✔✔ sound wave, photon
chemical ligand ANS✔✔ surface receptor
electrical field ANS✔✔ disturbance in the vicinity of excitable membrane
spontaneous ANS✔✔ inherent imbalances in leak pump system
voltage gated sodium channel ANS✔✔ .at resting potential (-70 mV)
from threshold peak potential (-50 mV to +30 mV)
from peak to resting potential (+30 mV to -70 mV)
voltage gated potassium channel ANS✔✔ at resting potential; delayed opening triggered at
threshold; remains closed to peak potential (-70 mV to +30 mV)
From peak potential through after hyper-polarization (+30 mV to -80 mV)
process of channels 1 ANS✔✔
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