budesonide MOA - Correct Answer glucocorticoid that limits to GI tract (less systemic
effects)
GI side effects of opioids - Correct Answer decrease activity of myenteric plexus (motility)
steps in cobalamin absorption - Correct Answer 1) bound to R protein in stomach
2) bound to intrinsic factor (pancreas) in proximal SI
3) absorbed in distal SI
minimum inhibitory concentration (MIC) - Correct Answer lowest concentration of drug to
inhibit bacterial growth
minimum bactericidal concentration (MBC) - Correct Answer lowest concentration that
kills >99.9% of bacteria used in MIC testing
breakpoint MIC - Correct Answer value above which plasma concentrations are unlikely to
be achieved
breakpoints depend on - Correct Answer PK/PD of drug (do not change based on infecting
organism)
susceptible (S) - Correct Answer MIC is less than the breakpoint
intermediate (I) - Correct Answer MIC is approaching breakpoint
resistant (R) - Correct Answer MIC is greater than breakpoint
T > MIC - Correct Answer time that drug concentration exceeds MIC of pathogen
(determines efficacy of time dependent antimicrobial)
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