Acute leukemia, aplastic anemia, or other bone marrow failure syndrome suspected
(hematology)
Thrombotic Thrombocytopenic Purpura (TTP) Answer An acute syndrome which causes
thrombocytopenia, microangiopathic hemolytic anemia and thrombosis in the
microvascular resulting in organ damage. Often presents with neurologic or renal
clinical manifestations but can affect any organ *Medical Emergency*
ADAMTS13 deficiency leads to increased von Willebrand factor and platelet
aggregation
Risk factors female gender and AA
90% mortality rate if untreated
TTP clinical presentation-Answer AMS, neuro dysfunction, fatigue w/ anemia,
microangiopathic anemia, petechiae, pallor, jaundice, dark urine from hemoglobinuria,
GI symptoms common, CP
TTP Diagnostic Eval-Answer CBC-hgb mod low (8-9), plt 20-50k, peripheral
smear-presence of schistocytes (fragmented RBCs)
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Easton. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.99. You're not tied to anything after your purchase.