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NURS 5463 - Mod 3 - Platelet Disorders Exam With Complete Solutions $9.99   Add to cart

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NURS 5463 - Mod 3 - Platelet Disorders Exam With Complete Solutions

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NURS 5463 - Mod 3 - Platelet Disorders Exam With Complete Solutions...

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  • November 3, 2024
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  • NURS 5463 - Mod 3 - Platelet Disorders
  • NURS 5463 - Mod 3 - Platelet Disorders
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NURS 5463 - Mod 3 - Platelet Disorders Exam
With Complete Solutions


Thrombocytopenia Risk of Bleeding - Answer >50,000 - Adq for hemostasis in most
cases

30-50k - rarely have purpura, even w/ significant trauma

10-30k - usually asymptomatic, increased risk for excessive bleeding w/ trauma,
spontaneous bleeding may occur but not common

<10k - spontaneous bleeds develop, petechiae present, medical emergency

*>50k indicated for invasive procedures (80-100 for surgery)



Causes of Thrombocytopenia - Answer-hemodilution (occurs post op, drop in 20-70%,
usually nadir in 2-4 days)

-Hypersplenism (platelets destroyed in the spleen)

-HIV

-Viral infections

-SLE



Medications that Cause Thrombocytopenia - Answer Sulfonamides

Quinine (tonic water)

Heparin

Eptifibatide (Integrillin)

Rifampin (Rifadin)

Beta lactam antibiotics (PCN, Cephalosporins)

Carbamazepine (Tegretol)

Levofloxacin (flouroquinolones)

, Vancomycin

Linezolid (Zyvox)

Abciximab (Reopro)

Tirofibab (Aggrastat)

Piperacillin

Valproic Acid (Depakote)

Phenytoin (Dilantin)

*antiplatelet agents*

Thrombocytopenic Emergencies - Answer Bleeding w/ platelets <50k

Urgently needed invasive procedure w/ platelets

Pregnancy w/ platelets <50k

Suspected thrombotic thrombocytopenic purpura (hematology)

Acute leukemia, aplastic anemia, or other bone marrow failure syndrome suspected
(hematology)



Thrombotic Thrombocytopenic Purpura (TTP) Answer An acute syndrome which causes
thrombocytopenia, microangiopathic hemolytic anemia and thrombosis in the
microvascular resulting in organ damage. Often presents with neurologic or renal
clinical manifestations but can affect any organ *Medical Emergency*

ADAMTS13 deficiency leads to increased von Willebrand factor and platelet
aggregation

Risk factors female gender and AA

90% mortality rate if untreated



TTP clinical presentation-Answer AMS, neuro dysfunction, fatigue w/ anemia,
microangiopathic anemia, petechiae, pallor, jaundice, dark urine from hemoglobinuria,
GI symptoms common, CP



TTP Diagnostic Eval-Answer CBC-hgb mod low (8-9), plt 20-50k, peripheral
smear-presence of schistocytes (fragmented RBCs)

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