BIOL 133 exam 3
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1. Which of the following mutations would likely be most B. Deletion of one
dangerous to a cell? nucleotide
A. Deletion of three nucleotides
B. Deletion of one nucleotide
C. Substitution of one nucleotide for another
2. ______________ are parts of __________ molecules A. Introns . . .
that do not contain information about a protein's pri- pre-mRNA
mary structure.
A. Introns . . . pre-mRNA
B. Introns . . . mRNA
C. Exons...pre-mRNA
D. Exons...mRNA
3. The genetic disease sickle cell anemia is due to a B. The mutation re-
mutation in the ²-globin gene (a component of hemo- sults in a Glu being
globin). replaced by a Val
Normal ²-globin allele (template strand): 3' T G A G G A
C T C C T C 5'
Sickle ²-globin allele (template strand): 3' T G A G G A
C A C C T C 5'
Which of the following statements best summarizes
the sickle cell mutation?
A. The mutation results in a Leu being replaced by a
His
B. The mutation results in a Glu being replaced by a
Val
C. The mutation results in a stop codon appearing in
the mRNA too early
4. During the process of transcription: B. one DNA strand
A. DNA polymerase adds nucleotides to the newly serves as a tem-
synthesized strand. plate.
B. one DNA strand serves as a template.
C. a supply of the nucleotides ACGT is required.
D. two new RNA molecules are produced.
5. What type of mutation has occurred? B. A shortened
Original DNA: 3' AGCCGCATA 5' protein
, BIOL 133 exam 3
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Mutated DNA: 3' AGCCGCATC 5'
A. A single amino acid replacement
B. A shortened protein
C. All amino acids in the protein change
D. There is no change in the protein (silent mutation).
6. Which of the following DNA strands is the template C5'GGAATGCC-
strand for this molecule of mRNA? GAAT 3'
5'AUUCGGCAUUCC 3'
A. 5'TAAGCCGTAAGG 3'
B. 5'GGAAUGCCGAAU 3'
C. 5'GGAATGCCGAAT 3'
D. 5'AUUCGGCAUUCC 3'
7. All of the following are directly required for protein A. DNA poly-
synthesis EXCEPT _____________________. merase
A. DNA polymerase
B. tRNA
C. ribosomes
D. RNA polymerase
8. Here is the amino acids sequence for a short piece of A. 5'AGAATTTT-
a protein: TTTGAGTAGG 3'
Pro-Thr-Gln-Lys-Asn-Ser
Which of the following is the DNA TEMPLATE strand
used to produce the mRNA that encodes this protein
sequence?
A. 5'AGAATTTTTTTGAGTAGG 3'
B. 5'GGATGAGTTTTTTTATCA 3'
C. 5'CCUACUCAAAAAAAUUCC 3'
D. 5'UUUUUAUCAUUGAGUAGG 3'
9. The genetic code is said to be "redundant" because C. one amino acid
_____________________________________. can have more
A. one anticodon can attach to several amino acids than one codon
B. there is more than one start codon
C. one amino acid can have more than one codon
D. one codon can signify more than one amino acid
10.
, BIOL 133 exam 3
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Which of the following sets of tRNA anticodons would D. 5'-AAA UGG
associate with the following mRNA during transla- AUU-3'
tion?
5'-AAU CCA UUU-3'
A. 5'-TTA GGT AAA-3'
B. 5'-UUA GGU AAA-3'
C. 5'-AAA TGG ATT-3'
D. 5'-AAA UGG AUU-3'
11. Which characteristic of the genetic code lowers the D. Redundancy
likelihood of a mutation causing a mutant phenotype?
A. Universality
B. Un-ambiguity
C. Non-overlapping
D. Redundancy
12. You are studying a protein and have sequenced the A. is too short.
DNA that encodes it. There is also a mutant version of
the protein that does not function correctly. When you
transcribe the DNA to obtain the mRNA sequence, you
find that at one position, there has been a mutation
from 5'UGC 3' to 5'UGA 3'. Using the genetic code, you
determine that this mutant protein
A. is too short.
B. has the amino acid Trp in place of the amino acid
Cys.
C. is too long.
D. has the amino acid Ser in place of the amino acid
Arg.
13. The primary pre-mRNA transcript is much longer than B. Introns have not
the mRNA that will eventually be translated. This can yet been removed
be explained by which of the following? from the transcript
A. The 5' cap has not yet been added to the transcript
B. Introns have not yet been removed from the tran-
script
C. Exons have not yet been added to the transcript
D. The poly-A tail is still on the primary transcript
14.
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1. Which of the following mutations would likely be most B. Deletion of one
dangerous to a cell? nucleotide
A. Deletion of three nucleotides
B. Deletion of one nucleotide
C. Substitution of one nucleotide for another
2. ______________ are parts of __________ molecules A. Introns . . .
that do not contain information about a protein's pri- pre-mRNA
mary structure.
A. Introns . . . pre-mRNA
B. Introns . . . mRNA
C. Exons...pre-mRNA
D. Exons...mRNA
3. The genetic disease sickle cell anemia is due to a B. The mutation re-
mutation in the ²-globin gene (a component of hemo- sults in a Glu being
globin). replaced by a Val
Normal ²-globin allele (template strand): 3' T G A G G A
C T C C T C 5'
Sickle ²-globin allele (template strand): 3' T G A G G A
C A C C T C 5'
Which of the following statements best summarizes
the sickle cell mutation?
A. The mutation results in a Leu being replaced by a
His
B. The mutation results in a Glu being replaced by a
Val
C. The mutation results in a stop codon appearing in
the mRNA too early
4. During the process of transcription: B. one DNA strand
A. DNA polymerase adds nucleotides to the newly serves as a tem-
synthesized strand. plate.
B. one DNA strand serves as a template.
C. a supply of the nucleotides ACGT is required.
D. two new RNA molecules are produced.
5. What type of mutation has occurred? B. A shortened
Original DNA: 3' AGCCGCATA 5' protein
, BIOL 133 exam 3
Study online at https://quizlet.com/_fvtnq4
Mutated DNA: 3' AGCCGCATC 5'
A. A single amino acid replacement
B. A shortened protein
C. All amino acids in the protein change
D. There is no change in the protein (silent mutation).
6. Which of the following DNA strands is the template C5'GGAATGCC-
strand for this molecule of mRNA? GAAT 3'
5'AUUCGGCAUUCC 3'
A. 5'TAAGCCGTAAGG 3'
B. 5'GGAAUGCCGAAU 3'
C. 5'GGAATGCCGAAT 3'
D. 5'AUUCGGCAUUCC 3'
7. All of the following are directly required for protein A. DNA poly-
synthesis EXCEPT _____________________. merase
A. DNA polymerase
B. tRNA
C. ribosomes
D. RNA polymerase
8. Here is the amino acids sequence for a short piece of A. 5'AGAATTTT-
a protein: TTTGAGTAGG 3'
Pro-Thr-Gln-Lys-Asn-Ser
Which of the following is the DNA TEMPLATE strand
used to produce the mRNA that encodes this protein
sequence?
A. 5'AGAATTTTTTTGAGTAGG 3'
B. 5'GGATGAGTTTTTTTATCA 3'
C. 5'CCUACUCAAAAAAAUUCC 3'
D. 5'UUUUUAUCAUUGAGUAGG 3'
9. The genetic code is said to be "redundant" because C. one amino acid
_____________________________________. can have more
A. one anticodon can attach to several amino acids than one codon
B. there is more than one start codon
C. one amino acid can have more than one codon
D. one codon can signify more than one amino acid
10.
, BIOL 133 exam 3
Study online at https://quizlet.com/_fvtnq4
Which of the following sets of tRNA anticodons would D. 5'-AAA UGG
associate with the following mRNA during transla- AUU-3'
tion?
5'-AAU CCA UUU-3'
A. 5'-TTA GGT AAA-3'
B. 5'-UUA GGU AAA-3'
C. 5'-AAA TGG ATT-3'
D. 5'-AAA UGG AUU-3'
11. Which characteristic of the genetic code lowers the D. Redundancy
likelihood of a mutation causing a mutant phenotype?
A. Universality
B. Un-ambiguity
C. Non-overlapping
D. Redundancy
12. You are studying a protein and have sequenced the A. is too short.
DNA that encodes it. There is also a mutant version of
the protein that does not function correctly. When you
transcribe the DNA to obtain the mRNA sequence, you
find that at one position, there has been a mutation
from 5'UGC 3' to 5'UGA 3'. Using the genetic code, you
determine that this mutant protein
A. is too short.
B. has the amino acid Trp in place of the amino acid
Cys.
C. is too long.
D. has the amino acid Ser in place of the amino acid
Arg.
13. The primary pre-mRNA transcript is much longer than B. Introns have not
the mRNA that will eventually be translated. This can yet been removed
be explained by which of the following? from the transcript
A. The 5' cap has not yet been added to the transcript
B. Introns have not yet been removed from the tran-
script
C. Exons have not yet been added to the transcript
D. The poly-A tail is still on the primary transcript
14.
