Exam (elaborations)
HMX Immunology Practice Questions 2024/2025 Solution solved 100% Passed!!
- Course
- Institution
HMX Immunology Practice Questions 2024/2025 Solution solved 100% Passed!!
[Show more]
Content preview
Passed!!2024/2025
HMX Immunology Practice
Questions
Which cells are tissue resident sentinel cells Answer: mast cell, macrophage,
dendritic cell
Which 2 cells are circulating blood cells that will enter tissue in response to
inflammation? Answer: Neutrophils, Monocytes
Mast cell Answer: Cells that release chemicals (such as histamine) that
promote inflammation.
Neutrophil Answer: Most abundant leukocyte, increase due to bacterial
infection, burns, and stress. Phagocyte that rapidly dies after ingesting microbe.
Macrophages Answer: Phagocyte that cleans up apoptotic cells.
When a monocyte moves into the tissues, it changes rapidly and becomes a
_____________ Answer: macrophage
Leukocyte adhesion deficiency (LAD) is a genetic defect that leads to recurrent
infections in the tissue and severe problems with wound healing. LAD patients
also develop severe gingivitis (infections and inflammation of the gums). In LAD,
leukocyte migration into tissues is severely impaired. All of these problems can be
traced back to a genetic defect. Of the genetic defects listed below, which is the
most likely cause of LAD? Answer: A mutation that introduces a stop codon
into a gene that encodes part of the LFA-1 molecule (leading to a truncated
protein).
, Passed!!
2024/2025
Toll-like receptors for bacterial PAMPs are found on/in the_________________
Answer: cell membrane
There are a few different proteins that act as inhibitors of NF-kB. There is a very
rare genetic disease in which one of these proteins, IkBa, is mutated. The
mutation substantially alters the stability of the IkBa protein. In patients with this
disease, IkBa protein expression does not change in response to stimuli that cause
IkBa degradation in healthy individuals. Consider the biological role of NF-kB
inhibitors. What are the most likely symptoms of this genetic defect? Answer:
Immunodeficiency with a susceptibility to bacterial infections.
The complement pathway initiated by host proteins that bind to microbial sugars
is called the ______________________ pathway. Answer: lectin pathway
SSRNA (single-stranded RNA) and dsDNA (double-stranded DNA) are present in
mammalian cells. Why don't our plasmacytoid dendritic cells activate an innate
immune response against these self nucleic acids that are necessary for normal
cellular function? Answer: The TLRs that recognize SSRNA and dsDNA are
sequestered in endosomes.
How can the antiviral state be propagated in the absence of immune cells?
Answer: Type I IFs are produced by infected epithelial cells; this induces
antiviral biochemical changes in the same cell and adjacent cells.
A child presents with recurrent bacterial infections. Of the genetic defects
described below, what is the most likely cause of her disease? Answer: A
mutation in the C3 gene that renders the C3 protein nonfunctional.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Schoolflix. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $14.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
81989 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now