,Table of Content 1i 1i
Chapter 01: Cellular Biology ....................................................................................................................................... 4
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Chapter 02: Genes and Genetic Diseases .................................................................................................................. 13
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Chapter 03: Epigenetics and Disease ......................................................................................................................... 23
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Chapter 04: Altered Cellular and Tissue Biology ...................................................................................................... 27
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Huether & McCance: Understanding Pathophysiology, 6th Edition ......................................................................... 39
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Chapter 06: Innate Immunity: Inflammation and Wound Healing Huether & McCance: Understanding Pathophysi
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ology, 6th Edition....................................................................................................................................................... 48
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Chapter 07: Adaptive Immunity ................................................................................................................................ 60
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Chapter 08: Infection and Defects in Mechanisms of Defense Huether & McCance: Understanding Pathophysiolo
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gy, 6th Edition............................................................................................................................................................ 66
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SINGTB.COM ............................................................................................................................................................... 74
Chapter 09: Stress and Disease .................................................................................................................................. 76
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Chapter 10: Biology, Clinical Manifestations, and Treatment of Cancer Huether & McCance: Understanding Path
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ophysiology, 6th Edition ............................................................................................................................................ 81
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Chapter 11: Cancer Epidemiology ............................................................................................................................. 87
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Chapter 12: Cancer in Children ................................................................................................................................. 91
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Chapter 13: Structure and Function of theNeurologic System Huether & McCance: Understanding Pathophysiolog
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y, 6th Edition ............................................................................................................................................................. 94
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Chapter 14: Pain, Temperature, Sleep, and Sensory Function Huether & McCance: Understanding Pathophysiolog
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y, 6th Edition............................................................................................................................................................ 105
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Chapter 15: Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function .............................. 116
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Chapter 16: Disorders of theCentral and Peripheral Nervous Systems and theNeuromuscular Junction ................ 126
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Chapter 17: Alterations of Neurologic Function in Children Huether & McCance: Understanding Pathophysiology
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, 6th Edition ............................................................................................................................................................. 138
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Chapter 18: Mechanisms of Hormonal Regulation.................................................................................................. 147
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Chapter 19: Alterations of Hormonal Regulation .................................................................................................... 156
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Chapter 20: Structure and Function of the Hematologic System Huether & McCance: Understanding Pathophysiol
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ogy, 6th Edition........................................................................................................................................................ 169
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Chapter 21: Alterations of Hematologic Function ................................................................................................... 176
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INGTB.COM ............................................................................................................................................................... 177
Chapter 22: Alterations of Hematologic Function in Children Huether & McCance: Understanding Pathophysiolo
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gy, 6th Edition ......................................................................................................................................................... 192
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Chapter 23: Structure and Function of the Cardiovascular and Lymphatic Systems Huether & McCance: Understa
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nding Pathophysiology, 6th Edition ......................................................................................................................... 200
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Chapter 24: Alterations of Cardiovascular Function ............................................................................................... 210
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1i 1i O .................................................................................................................................................................. 210
SINGTB.COM ............................................................................................................................................................. 223
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1i 1i O .................................................................................................................................................................. 226
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Chapter 25: Alterations of Cardiovascular Function in Children Huether & McCance: Understanding Pathophysiol
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ogy, 6th Edition........................................................................................................................................................ 229
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SNT
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Chapter 26: Structure and Function of the Pulmonary System Huether & McCance: Understanding Pathophysiolo
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gy, 6th Edition.......................................................................................................................................................... 236
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Chapter 27: Alterations of Pulmonary Function ...................................................................................................... 245
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, Chapter 28: Alterations of Pulmonary Function in Children Huether & McCance: Understanding Pathophysiology
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, 6th Edition ............................................................................................................................................................. 257
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Chapter 29: Structure and Function of the Renal and Urologic Systems Huether & McCance: Understanding Path
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ophysiology, 6th Edition ......................................................................................................................................... 265
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Chapter 30: Alterations of Renal and Urinary Tract Function Huether & McCance: Understanding Pathophysiolog
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y, 6th Edition ........................................................................................................................................................... 273
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Chapter 31: Alterations of Renal and Urinary Tract Function in Children Huether & McCance: Understanding Pat
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hophysiology, 6th Edition ....................................................................................................................................... 280
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Chapter 32: Structure and Function of the Reproductive Systems Huether & McCance: Understanding Pathophysi
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ology, 6th Edition..................................................................................................................................................... 286
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Chapter 33: Alterations of the Female Reproductive System Huether & McCance: Understanding Pathophysiology,
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6th Edition .............................................................................................................................................................. 295
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Chapter 34: Alterations of the Male Reproductive System...................................................................................... 300
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Chapter 35: Structure and Function of the Digestive System Huether & McCance: Understanding Pathophysiology
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, 6th Edition ............................................................................................................................................................. 305
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Chapter 36: Alterations of Digestive Function ........................................................................................................ 312
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Chapter 37: Alterations of Digestive Function in Children ..................................................................................... 325
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Chapter 38: Structure and Function of the Musculoskeletal System Huether & McCance: Understanding Pathophy
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siology, 6th Edition .................................................................................................................................................. 334
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Chapter 39: Alterations of Musculoskeletal Function ............................................................................................. 342
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Chapter 40: Alterations of Musculoskeletal Function in Children Huether & McCance: Understanding Pathophysi
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ology, 6th Edition..................................................................................................................................................... 352
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Chapter 41: Structure, Function, and Disorders of the Integument Huether & McCance: Understanding Pathophysi
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ology, 6th Edition..................................................................................................................................................... 357
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Chapter 42: Alterations of the Integument in Children............................................................................................ 366
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, Chapter 01: Cellular Biology
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Huether & McCance: Understanding Pathophysiology, 6th Edition
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MULTIPLE CHOICE 1i
1. A student is observing a cell under the microscope. It is observed to have supercoiled DNA
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with histones. Which of the following would also be observed by the student?
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a. A single circular chromosome
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b. A nucleus 1i
c. Free-floating nuclear material 1i 1i
d. No organelles 1i
ANS: B 1 i
The cell described is a eukaryotic cell, so it has histones and a supercoiled DNA within its nu
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cleus; thus, the nucleus should be observed. A single circular chromosome called a prokaryot
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e contains free-floating nuclear material but has no organelles.
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REF: p. 2 1i 1i
2. A nurse is instructing the staff about cellular functions. Which cellular function is the nurse
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describing when an isolated cell absorbs oxygen and uses it to transform nutrients to energy?
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a. Metabolic absorption 1i
b. Communication
c. Secretion
d. Respiration
ANS: D 1i
The cell’s ability to absorb oxygen is referred to as respiration while its communication ability invol
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ves maintenance of a steady dynamic state, metabolic absorption provides nutrition, and secretion a
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llows for the synthesizing of new substances.
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REF: p. 2 1i 1i
3. A eukaryotic cell is undergoing DNA replication. In which region of the cell would most of
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the genetic information be contained?
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a. Mitochondria
b. Ribosome
c. Nucleolus
d. Nucleus Cytoplasm 1i
ANS: C 1i
The region of the cell that contains genetic material, including a large amount of ribonucleic a
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cid, most of the DNA, and DNA-
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binding proteins, is the nucleolus, which is located within the cell’s nucleus. Mitochondria is
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associated with cellular respiration, while ribosomes are involved with protein manufacturing
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. Cytoplasm is a fluid filling that is a component of the cell.
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REF: p. 2 1i 1i
