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AOCNP Test Review 2024 Exam Questions With Correct Answers.

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AOCNP Test Review 2024 Exam Questions With Correct Answers. Treatments that place individuals at increased risk for infection - answerChemotherapy treatments including high-dose cyclophosphamide, doxorubicin, docetaxel, or alemtuzumab. Colony stimulating factors (CSF) - answer**GM-CSF : growth ...

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  • November 11, 2024
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  • 2024/2025
  • Exam (elaborations)
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  • AOCNP
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Thebright
©THEBRIGHT EXAM SOLUTIONS

11/6/2024 12:22 AM


AOCNP Test Review 2024 Exam Questions
With Correct Answers.


Treatments that place individuals at increased risk for infection - answer✔Chemotherapy treatments
including high-dose cyclophosphamide, doxorubicin, docetaxel, or alemtuzumab.

Colony stimulating factors (CSF) - answer✔**GM-CSF : growth factor for hematopoietic stem cells and
granulocyte/monocytes

**M-CSF (macrophage): essential for macrophage production

**G-CSF (granulocyte) :essential for neutrophils

**Erythropoietin (EPO): growth factor for RBC

Filgrastim (Neupogen)

Pegfilgrastim (Neulasta)

Tbo-filgrastim (Granix) - answer✔Common side effects: mild to moderate bone pain

Used to patients at risk of experiencing treatment induced neutropenia

Major benefit: reducing the possibility of myelosuppression and permitting the continuation of
therapeutic chemotherapy doses

Filgrastim (Neupogen) - answer✔Dose: 5 µg per kilogram per day. Begin 24 to 72 hours after completion
of chemotherapy and continue through the post nadir period.

Pegfilgrastim (Neulasta) - answer✔That was: 6 mg per cycle. Again 1 to 3 days post chemotherapy.
Administer as a single 6 mg injection once per cycle. Do not administer in the period beginning 14 days
before until 24 hours after administration of chemotherapy.

Antimicrobial prophylaxis for infection - answer✔Low risk: no prophylaxis Recommended unless the
patient has prior herpes simplex virus episode.



Intermediate risk:

Bacterial: consider Fluoroquinolone

, ©THEBRIGHT EXAM SOLUTIONS

11/6/2024 12:22 AM

Fungal: consider fluconazole during neutropenia and if mucositis is anticipated

Viral: during neutropenia and at least 30 days after transplantation



High risk:

Bacterial: consider fluoroquinolone

Fungal: consider fluconazole or other anti-fungal agent

Viral: during neutropenia and at least 30 days after transplantation

Graft versus host disease: penicillin andtrimethroprim/sulfamethoxazole (tmp/smx) Or equivalent for
allogenic heamatopoetic Stem cell transplant recipients

Alemtuzumab: TMP/SMX

Complete diagnostic work up for neutropenic fever - answer✔Blood cultures: bacterial, viral, and fungal

BUN, electrolytes, and creatinine

Chest x-ray

CBC and differential

Liver function test

Pulse oximetry

Site-specific cytology and cultures

Urinanalysis

ANC calculation - answer✔WBC x [(% segs + % bands)/100]

aplastic anemia - answer✔a normocytic-normochromic type of anemia characterized by the failure of
bone marrow to produce red blood cells

hemolytic anemia - answer✔characterized by an inadequate number of circulating red blood cells due to
the premature destruction of red blood cells by the spleen

deficiency anemia - answer✔anemia caused by lack of necessary nutrients

B12, folate, and iron

Anemia # of RBC/ MCV - answer✔Microcytic. Normocytic. Macrocyctic.

Microcytic anemia with ↓ serum iron, ↓ total iron-binding capacity (TIBC), and normal or ↑ ferritin. -
answer✔cells smaller than normal

, ©THEBRIGHT EXAM SOLUTIONS

11/6/2024 12:22 AM

Iron deficiency

macrocytic anemia - answer✔due to folate or vitamin B12(cobalamin) deficiency (megaloblastic
anemia), THF-M --> VitB12-M --> Methionine, (transfer of methyl groups)

erythrpoietin (EPO) - answer✔Stimulates development of RBC production

Triggered to release by reduced oxygen level of RBC mass trigger from the kidney

Labs to check in anemia - answer✔CBC with diff

Peripheral smear

Reticulocyte count

Iron studies: serum iron, total iron binding capacity, ferritin

Vitamin B 12

Full eight red cell




If these are not diagnostic these may be added

Fractionated Bilirubin

Occult stool

Coombs test

Haptoglobin level

Hemoglobin electrophoresis

Bone marrow biopsy

Grades of Anemia - answer✔Grade 1 mile: hemoglobin of 10 to 12

Great to moderate: hemoglobin of 8 to 10

Grade 3 severe: hemoglobin of 6.707.9

Great for life-threatening: hemoglobin below 6.5

Treatments that cause thrombocytopenia More than 50% of the time: - answer✔Topotecan

MOPP

, ©THEBRIGHT EXAM SOLUTIONS

11/6/2024 12:22 AM

ESHAP

GEM/CIS

PCDE

Normal lifespan of a platelet - answer✔8-10 days

Normal platelet range - answer✔150,000-400,000/mm3

Thrombocytopenia - answer✔low platelet count, Less than 100



Decrease platelet production can occur in patients with cancer as the result of colon tumor invasion of
the bone marrow or spleen, bone marrow suppression, aplastic anemia

Herbal agents that can cause thrombocytopenia - answer✔Ginkgo biloba, garlic, ginger, turmeric

Medication that can cause anemia - answer✔Aspirin

Heparin

Digoxin

Thiazide diuretics

NSAIDS

PHENYTOIN

quinine

Abx

Tricyclic anti depressant

Benzene

Interleukin-11 (platelet growth factor) - answer✔Oprelvekin. Thrombocytopenia related to
chemotherapy

Steroids may also be used

Primary Cachexia - answer✔Anorexia-Cachexia syndrome

Decreased gluconeogenesis

Alterations in glucose metabolism

Increased metabolic rate

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