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Pediatric Acute Lymphoblastic Leukemia Exam Questions with Verified Answers (Graded A+) $7.99   Add to cart

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Pediatric Acute Lymphoblastic Leukemia Exam Questions with Verified Answers (Graded A+)

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Pediatric Acute Lymphoblastic Leukemia Exam Questions with Verified Answers (Graded A+) What is risk stratum of pediatric ALL using patient case? - Answers What labs are suggestive of ALL? - Answers WBC: 70.3 (5-15 is normal) Hgb: 5.8 (10.5-13.5) Plt: 36 (150 - 400) Blasts: 89.0 Wha...

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  • November 11, 2024
  • 8
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • Pediatric Acute Lymphoblastic Leukemia
  • Pediatric Acute Lymphoblastic Leukemia
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Pediatric Acute Lymphoblastic Leukemia Exam Questions with Verified Answers (Graded A+)

What is risk stratum of pediatric ALL using patient case? - Answers

What labs are suggestive of ALL? - Answers WBC: 70.3 (5-15 is normal)



Hgb: 5.8 (10.5-13.5)



Plt: 36 (150 - 400)



Blasts: 89.0

What is the etiology? - Answers most common pediatric malignancy (leading cause of childhood cancer
death)



overall survival rates currently ~90%



peak incidence 2-5 years old



boys > girls, white hispanic > Black, Asian



higher incidence in industrial countries

Diagnosis of ALL? - Answers symptoms are are non-specific



procedures (bone marrow biopsy and lumbar puncture)

Pathophysiology of ALL? - Answers T lymphocyte (10%)



B lymphocyte (90%)

What is CNS Status? - Answers CNS 1: no leukemia cells present on CSF studies

, CNS 2: less than 5 WBCs + Blasts on CSF studies



CNS 3: greater than equal to 5 WBCs + Blasts on CSF studies

What is important to know about intrathecal chemo? - Answers direct injection into CNS



used for both treatment of CNS disease and prophylaxis against development of CNS disease (systemic
chemo has limited CNS penetration)



limited systemic penetration



*most common - intrathecal cytarabine*

- may also give methotrexate or "triple IT" (cytarabine + methotrexate + hydrocortisone)

What is the treatment of TLS? - Answers start hydration at 1.5 to 2x maintenance rate



give *single dose of raburicase 0.2mg/kg; cap dose at 6mg* --expensive / will not get rid of new uric acid
production



*start allopurinol 10/mg/kg/day divided TID* --inhibit xanthine oxidase and prevent uric acid crystals



*start sevelamer 800mg TID with meals* -- prevent calcium / phosphorus precipitate formation -- does
not do anything for the phos that is there (this is a phos binder)

What is TLS? - Answers tumor lysis syndrome (fairly common in ALL)



tumor cells lyse (either spontaneously or as a result of chemotherapy) -- will release all of the
intracellular components (DNA)

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