Pharmacology of type 2 Diabetes Exam Bank Solution Manual Latest Update 100% Pass
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Pharmacology of type 2 Diabetes
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Pharmacology Of Type 2 Diabetes
Pharmacology of type 2 Diabetes Exam Bank Solution Manual Latest Update 100% Pass
what should be done with the diet in type 2 diabetes? - Answers decrease carbohydrate intake
what are the 8 drugs which can be used in type 2 diabetes? - Answers Biguanides
Sulphonyureas
Thiazolidinediones
α-glu...
Pharmacology of type 2 Diabetes Exam Bank Solution Manual Latest Update 100% Pass
what should be done with the diet in type 2 diabetes? - Answers decrease carbohydrate intake
what are the 8 drugs which can be used in type 2 diabetes? - Answers Biguanides
Sulphonyureas
Thiazolidinediones
α-glucosidase inhibitors
meglitinides
Exenatide
Dipeptidyl peptidase 4 inhibitors
insulin
when were phenformin and metformin introduced? - Answers 1957
when was phenformin withdrawn? - Answers 1970s
what are the biguanides? - Answers phenformin
metformin
where are biguanides absorbed? - Answers the small intestine
how are biguanides excreted? - Answers in the urine. they aren't bound to plasma protein.
how do biguanides work? - Answers decrease hepatic glucose production
potentiate insulins action on muscle and adipose
stimulate glycolysis in tissues
stimulate glucose uptake
stimulate lactate production
what do biguanides not affect - Answers insulin release
glucagonr elease
growth hormone
cortisol
, somatostatin
what are the half lives of the biguanides? - Answers 2 hours
what substance absorption is affected by biguanides? - Answers folate and vit B12
what are the side effects of biguanides? - Answers diarrhoea, nausea and metallic taste
what side effects which are caused by other diabetic medicines are not caused by biguanides? - Answers
hypoglycaemia
stimulation of appetite
weight gain
what are biguanides given with? - Answers sulphonylureas
thiazolidenediones
insulin
what do biguanides do for diabetic complications? - Answers reduce microvascular complications
what did Janbon do and when? - Answers showed that sulphonamides cause hypoglycaemia in animals
1942
what drugs were used and developed in 1955 in T2DM? - Answers carbutamide (1-butyl-2-
sulphonylurea) was used
tolbutamide was developed which was devoid of antibacterial activity
what are the second generation sulphonylureas and when were they introduced? - Answers
Glibenclamide
Gliclazide
Glimepiride
Glipizide
Gliquidone
1980s
how do sulphonylureas work acutely? - Answers increase insulin release
increase plasma insulin concentration
decrease hepatic clearance of insulin
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