NURS 5463 - Mod 3 - Platelet Disorders Exam Study Guide.
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Course
Nurs 5463
Institution
Nurs 5463
NURS 5463 - Mod 3 - Platelet Disorders
Exam Study Guide.
Thrombocytopenia Risk of Bleeding - answer>50,000 - Adq for hemostasis in most cases
30-50k - rarely have purpura, even w/ significant trauma
10-30k - usually asymptomatic, increased risk for excessive bleeding w/ trauma, spontaneous b...
Suspected acute leukemia, aplastic anemia or other bone marrow failure syndrome (hematology)
Thrombotic Thrombocytopenic Purpura (TTP) - answer✔An acute syndrome which causes
thrombocytopenia, microangiopathic hemolytic anemia and thrombosis in the microvascular resulting in
organ damage. Often presents with neurologic or renal clinical manifestations (but can affect any organ)
* Medical Emergency *
ADAMTS13 deficiency - leads to increased von Willebrand factor and platelet aggregation
Risk factors - female gender and AA
Mortality rate of 90% if untreated
TTP clinical presentation - answer✔AMS, neuro dysfunction, fatigue w/ anemia, microangiopathic
anemia, petechiae, pallor, jaundice, dark urine from hemoglobinuria, GI symptoms are common, CP
TTP Diagnostic Eval - answer✔CBC - hgb mod low (8-9), plt 20-50k, peripheral smear - presence of
schistocytes (fragmented RBCs)
PT/aPTT - normal
haptoglobin - low
Dimer - normal to mildly elevated
fibrinogen - high normal to high
BUN/Crea - elevated if renal involvement
Lactic dehydrogenase (LDH) - (normal <200), usually elevated up to 1000
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