PBL Spring 2021 Exam 1 Drugs
Atropine - Class - correct answer anticholinergic, antimuscarinic
Atropine - MOA - correct answer Blocks ACh @ parasympathetic receptors of
smooth muscle, secretory glands & within CNS
- reverses the muscarinic effects seen in AChE Inhibitor overdose (cholinergic crisis)
- NOT effective on nicotinic receptors
Atropine - Side Effects - correct answer tachycardia, xerostomia, nausea, headache,
dizziness, blurred vision
Edrophonium Chloride - Class - correct answer parasympathomimetic, AChE
Inhibitor, diagnostic agent
Edrophonium Chloride - MOA - correct answer inhibits AChE - inhibits hydrolysis of
ACh - helps transmit nerve impulses across the NMJ
Edrophonium Chloride - Side Effects - correct answer may induce a cholinergic crisis
(nausea, vomiting, diarrhea, excessive salivation/sweating, bradycardia/tachycardia, bronchospasm)
Prednisone - Class - correct answer corticosteroid
Prednisone - MOA - correct answer suppresses movement of PMN leukocytes &
decreases capillary permeability (decreases inflammation/suppresses immune system by lowering
activity of the lymphatic system)
Prednisone - Side Effects - correct answer hypertension, Cushing Syndrome-like
effects, bone fractures, osteoporosis, poor wound healing, increased risk of infection
, Azathioprine - Class - correct answer immunosuppressant
Azathioprine - MOA - correct answer inhibits intracellular purine synthesis
(imidazolyl derivative of mercaptopurine) - gets incorporated into replicating DNA & stops it
Azathioprine - Side Effects - correct answer nausea, vomiting, stomatitis,
pancreatitis, hepatotoxicity, jaundice, leukopenia, thrombocytopenia, anemia, bleeding
Mycophenolate Mofetil - Class - correct answer immunosuppressant
Mycophenolate Mofetil - MOA - correct answer prodrug of mycophenolic acid
(MPA)
- induces apoptosis of activated T-cells
- also induces inosine monophosphate dehydrogenase (enzyme that creates guanosine nucleotides) --
B/T Lymphs are then unable to replicate
Mycophenolate Mofetil - Side Effects - correct answer diarrhea, constipation,
tremor, dizziness, hypertension, leukopenia, thrombocytopenia, anemia, muscle wasting, arthralgia
Pyridostigmine - Class - correct answer AChE inhibitor
Pyridostigmine - MOA - correct answer helps transmit nerve impulses across NMJ
- inhibits AChE so it doesn't break down ACh & is able to potentiate impulses
Pyridostigmine - Side Effects - correct answer dizziness, headache, sweating,
nausea, respiratory depression, bronchospasm, laryngospasm, tachycardia, dysrhythmia, AV block,
miosis, blurred vision, lacrimation, visual changes
Ibuprofen - Class - correct answer NSAID
Ibuprofen - MOA - correct answer - inhibits COX1/2 enzymes -- leading to decreased
formation of prostaglandin/inflammatory precursors
