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BRS PHYSIOLOGY EXAM QUESTIONS WITH COMPLETE SOLUTIONS VERIFIED

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BRS PHYSIOLOGY EXAM QUESTIONS WITH COMPLETE SOLUTIONS VERIFIED Total body water 60% of body weight is due to water Total body water composition 1. ICF=2/3 of body water. K, Mg, Protein, organic phosphate 2. ECF=1/3 of body water. Interstitial fluid (3/4 of ECF, little protein) and plasma (1/4 ...

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  • November 14, 2024
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BRS PHYSIOLOGY EXAM QUESTIONS WITH COMPLETE

SOLUTIONS VERIFIED

Total body water

60% of body weight is due to water

Total body water composition

1. ICF=2/3 of body water. K, Mg, Protein, organic phosphate

2. ECF=1/3 of body water. Interstitial fluid (3/4 of ECF, little protein) and plasma (1/4 of

ECF). Na, Cl, HCO3

60-40-20 rule

1. TBW=60% of body weight

2. ICF=40% of body weight

3. ECF=20% of body weight



TBW=ICF+ECF

Volume of distribution

Vd=Amount (injected-excreted)/Concentration

Osmolarity of ECF and ICF

Are equal at steady state.

Infusion of isotonic NaCl

1.ECF volume increases, but osmolarity unchanged so water doesn't shift between

compartments

2. Protein conc and HCT decrease bc ECF fluid dilutes it.

,3. Since isotonic, the RBCs don't change in size however.

4. BP inc bc ECF volume inc

Diarrhea=Loss of isotonic fluid (AKA iso-osmotic volume contraction)

1. ECF volume decreases, but iso again so no shift.

2. Protein conc and HCT increase bc of the loss of ECF

3. Since isotonic, the RBCs don't change in size.

4. BP dec bc ECF volume dec

Excessive NaCl intake=hyperosmotic volume expansion

1. Osmolarity of ECF increases bc osmoses of NaCL added.

2. Water therefore shifts from ICF to ECF (to dilute it for equilibrium). This increases the

osmolarity of the ICF and decreases the ECF osmolarity

3. As a result of the shift out of cells, ECF volume increases and ICF volume decreases.

4. Protein conc and HCT decrease because of the increase in ECF volume.

5. BP increases bc ECF increases

Sweating in a desert=loss of water (AKA hyper-osmotic volume contraction)

1. Osmolarity of ECF increases because sweat is hyposmotic (therefore mostly water,

not salt is lost)

2. ECF volume decreases because water is lost.

3. Water shifts from ICF to ECF and therefore ICF osmolarity increases and ICF volume

decreases.

4. Plasma protein increases because of the decrease in ECF

5. HCT is unchanged bc water shifts out of RBCs dec their voluming.

, Syndrome of inappropriate antidiuretic hormone (SIADH)=gain of water

(hyposmotic volume expansion)

1. Excess water is retained therefore ECF osmolarity decreases

2. ECF volume increases. Water then shifts into cells therefore ICF osmolarity

decreases and ICF volume increases.

3. Plasma protein conc decreases bc of the increase in ECF volume

4. HCT is unchanged bc water into RBC inc their volume

Adrenocortical insufficiency

1. Osmolarity of ECF decreases. Lack of aldosterone then decreases NaCl reabsorption

and more is excreted than reabsorbed so losing it.

2. ECF volume dec bc water shifts into cells since ECF is hyposmotic.

3. ICF osmolarity decreases and its volume inc due to the shift into cells.

4. HCT increases bc dec ECF volume and RBCs swell bc of water entry into cells

5. APB decreases due to the dec in ECF volume (plasma and interstitial)

Summary of shifts

Y=osmolarity

X=volume

-First 2 on left are iso-osmotic therefore no shift between ICF and ECF (ICF stays the

same)

-Middle are hyper osmotic (high Y) therefore shifts from ICF to ECF (Low ICF)

-Right are hypo osmotic (low Y) therefore shifts from the ECF to the ICF

Renal clearance

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