A pdf lecture notes on Jaundice in paediatrics.
The main objectives of the presentation are to enable the student be able to:
Define Jaundice
Understand the causes and risk factors
Clinical presentation of jaundice
Diagnose jaundice
Manage effectively.
, Introduction
Bilirubin -breakdown of hemoglobin
Unconjugated bilirubin (insoluble in water, lipid
soluble) transported to liver- Bound to albumin
Transported into hepatocyte (Ligandin / y-
protein ) & conjugated - With glucuronic acid →
now water soluble
Secreted into bile
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