Summary
Samenvatting overzicht alle differentiaal diagnoses hematologie
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overzicht alle differentiaal diagnoses hematologie
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Differentiaal diagnose hemato1. kliniek
2. bloedbeeld
3. kliniek compatibel met bloedbeeld
a. leeftijd
i. jong: mononucleose, ALL, AML (eerder volwassene)
ii. medium: CML, CLL, hairy cell leukemie (man)
iii. oud: B- CLL, myelodysplasie, AML
iv. bimodaal: Hodgkin
b. epidemo
Typisch kenmerk Aandoening
Gumprechtste schollen (lymfocyten) CLL
Hepcidine stijging Anemie door chronische ziekten
Sferocytose Hemolytische anemie
Elliptocytose
Stomatocytose
Botpijn en botafwijking Thalassemie
Myelofibrose
ALL
Botmetas
JAK2 mutatie Polycytemia rubra
Essentiele trombocytose
Myelofibrose
CALR mutatie Essentiele trombocytose
Philadelphia chromosoom CML
Chloromen: exoftalmie, cutaan, tandvlees AML
DIC Acute promyelocyten leukemie (M3) =>
urgentie!
Sternberg reed cellen Ziekte van Hodgkin
Plasmocytose Multiple myeloom
Amyloidose
Agranulocytose
Cirrose
MGUS
Hoge sedimentatie Infectie
Hypernefroom
Multiple myeloom
Punched out lesions Multiple myeloom
Macroglobulinemia IgM Waldenstrom
Mucosale bloedingen
Haptoglobine daling Hemolyse
Loodvergiftiging Sideroblastenanemie
Auerstaaf AML
, Differentiaal diagnose hemato
1. obv kliniek
Zonder LN of hepatosplenomegalie DD
ANEMIE => MCV berekenen
Zonder B - microcytair
Zonder klieren - normocytair
Zonder organomegalie - macrocytair
Zonder infecties
ANEMIE - toxisch
Sluipend - aplasie
Zonder B - myeloydysplasie
Met infecties - preleukemie
PANCYTOPENIE - acute leukemie
+ infectie - DIC
+ mucositis
+ bloedingen/petechien
+ B- symptomen
Geisoleerde bloedingsneiging Plaatjes vs stolling
Plaatjes - > Thrombopenie vs trombopathie
Botpijn/ patho fractuur - multiple myeloom
- botmetas (hypercalcemie)
Klinische hypercalcemie (verward, - multiple myeloom
constipatie, dorst) + algemene achteruitgang - metas
Trombose op jonge leeftijd Trombofilie
Repetitieve trombose
Vermoeidheid - Anemie
- Polycytemia vera
- waldenstorm
hypercalcemie kan ook na hyperparathyroidose (denk niersteen!)
hypercalcemie: dorst > eerst diabetes uitsluiten (hyperglycemie?)
infecties - > cytopenie
Zonder LN, MET hepatosplenomegalie DD
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