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Hematology – Rodaks UPDATED ACTUAL Questions and CORRECT Answers
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ematology – Rodaks UPDATED ACTUAL Questions and CORRECT Answers RBC relies on what type of energy production - CORRECT ANSWER- anaerobic glycolysis exchange of o2 and co2 is - CORRECT ANSWER- passive through what process is glucose catabolized to pyruvate - CORRECT ANSWER- embden-meyerhof...

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  • November 16, 2024
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  • 2024/2025
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Hematology – Rodaks UPDATED ACTUAL
Questions and CORRECT Answers
RBC relies on what type of energy production - CORRECT ANSWER- ✔✔anaerobic
glycolysis


exchange of o2 and co2 is - CORRECT ANSWER- ✔✔passive


through what process is glucose catabolized to pyruvate - CORRECT ANSWER-
✔✔embden-meyerhoff pathway EMP


how many ATP molecules is used up and generated using EMP - CORRECT ANSWER-
✔✔2 are used up
4 are generating
NET ATP production = 2


the 3 phases of glycolysis - CORRECT ANSWER- ✔✔1st - glucose phosphorylation,
isomerization and diphosphorylation (yields fructose 1,6-biphosphate ---> G3P)


2nd - conversion of G3P to 3-phosphoglycerate 3-PG


3rd - conversion of 3-PG to pyruvate and generates ATP


the glycolysis diversion pathways - CORRECT ANSWER- ✔✔hexose monophosphate
pathway HMP
methemoglobin reductase pathway
rapoport-luebering pathway


HMP is also knows as - CORRECT ANSWER- ✔✔pentose phosphate shunt



aerobic glycolysis - CORRECT ANSWER- ✔✔HMP

, what arises from O2 reduction in the cell - CORRECT ANSWER- ✔✔peroxide production



pathway that detoxifies peroxide - CORRECT ANSWER- ✔✔HMP



steps in the HMP pathway - CORRECT ANSWER- ✔✔1 - G6P is converted to ribulose 5-
phosphate (via G6PD enzyme)


2 - NADP is converted to NADPH (reduced form)


3 - NADPH reduces oxidized glutathione to reduced glutathione (using glutathione reductase)


4 - reduced glutathione becomes oxidized as it reduces peroxide to water and oxygen (via
glutatione peroxidase)


what is the most important enzyme in the HMP pathway, and why - CORRECT ANSWER-
✔✔G6PD (glucose-6-phosphate dehydrogenase)


without G6PD NADPH cannot be produced for glutathione reduction


erythrocytes are vulnerable to oxidative damage


what results in a G6PD deficiency - CORRECT ANSWER- ✔✔hereditary nonspherocytic
anemia


how does peroxide affect heme iron - CORRECT ANSWER- ✔✔oxidizes iron from ferrous -
--> ferric


how is methemoglobin reduced - CORRECT ANSWER- ✔✔NADPH in the presence of
methemoglobin reductase (aka cytochrome b5 reductase)

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