Chapter 11 CHEM 111 Exam 44 Questions with Verified Answers
Transdermal drug delivery system - CORRECT ANSWER Facilitate the passage of therapeutic quantities of drug substances through the skin and into the general circulation for their systemic effects
Stoughton - CORRECT ANSWER First conce...
Chapter 11 CHEM 111 Exam 44 Questions with Verified
Answers
Transdermal drug delivery system - CORRECT ANSWER Facilitate the passage of
therapeutic quantities of drug substances through the skin and into the general
circulation for their systemic effects
Stoughton - CORRECT ANSWER First conceived of the percutaneous absorption of
drug substances
Transderm Scop (Baxter) - CORRECT ANSWER First transdermal system
Baxter - CORRECT ANSWER used for prevention of nausea and vomiting
associated with travel, particularly sea
Stratum corneum - CORRECT ANSWER Major rate-limiting barrier to transdermal
drug transport
100 to 800 - CORRECT ANSWER Drugs with this range of molecular weight can
permeate skin with adequate lipid and aqueous solubility
400 or less - CORRECT ANSWER Ideal molecular weight for transdermal drug
delivery
Chemical skin penetration enhancers - CORRECT ANSWER Increase skin
permeability by reversibly damaging or altering the physicochemical nature of the
stratum corneum to to reduce its diffusional resistance
Iontophoresis - CORRECT ANSWER delivery of a charged chemical compound
across the skin membrane using an electrical field
, Sonophoresis - CORRECT ANSWER Also known as high-frequency ultrasound. It
can influence the integrity of the stratum corneum and thus affect its
penetrability.
Shed of black rat snake - CORRECT ANSWER Alternative in in vitro studies which is
a nonliving, pure stratum corneum, hairless, and similar to human skin but slightly
less permeable
Living Skin Equivalent Testskins - CORRECT ANSWER It is developed as an
alternative for dermal absorption studies
Monolithic system - CORRECT ANSWER Incorporate a drug matrix layer between
the backing and frontal layers
Drug matrix layer - CORRECT ANSWER Composed of polymeric material in which
drug is dispersed
Polymer matrix - CORRECT ANSWER Controls the rate at which the drug is
released for percutaneous absorption
membrane-controlled transdermal systems - CORRECT ANSWER Designed to
contain a drug reservoir or "pouch", usually in liquid or gel form, a rate-controlling
membrane, and backing, adhesive and protecting layers
Device - CORRECT ANSWER If the drug delivered to the stratum corneum at a rate
less that the absorption capacity this is the controlling factor
Skin - CORRECT ANSWER The controlling factor if the drug id delivered to the skin
area to saturation
Artificial or natural membranes - CORRECT ANSWER Controls the rate of drug
transport in all TDDSs, monolithic and membrane
Occlusive backing membrane - CORRECT ANSWER Protect the system from
environmental entry and from loss of drug from system or moisture from the skin
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