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Kuby Immunology Chapter 16 Tolerance, Autoimmunity, and Transplantation
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Kuby Immunology Chapter 16 Tolerance, Autoimmunity, and Transplantation
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Kuby Immunology Chapter 16 Tolerance, Autoimmunity, and Transplanttion
Study online at https://quizlet.com/_f7689v
1. 1. Central tolerance: *All of the above*
A. is the first step of tolerance mechanisms.
B. affects both T cells and B cells.
C. deletes cells that are autoreactive.
D. occurs in the bone marrow and thymus.
E. All of the above.
2. 2. Which of the following statements does NOT de- *They only affect B
scribe tolerogens accurately? cells*
A. They can be the same molecules as immunogens.
B. They lead cells to become unresponsive.
C. They are part of peripheral tolerance.
D. They only affect B cells.
E. All of the above.
3. 3. The tolerogenic response: *results in cells
becoming non-re-
A. is not antigen specific. sponsive*
B. leads to apoptosis but not anergy.
C. results in cells becoming non-responsive.
D. depends of the presentation context.
E. affects T cells only.
4. 4. Tolerance is promoted by all of the following circum- **presence of ad-
stances EXCEPT: juvant**
A. high doses of antigen.
B. persistent antigen.
C. oral introduction of antigen.
D. presence of adjuvant.
E. low levels of costimulation.
5. 5. Tolerance is promoted by: **All of the above**
A. induction of anergy.
B. induction of apoptosis.
C. regulation of activity of cells.
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, Kuby Immunology Chapter 16 Tolerance, Autoimmunity, and Transplant
tion
Study online at https://quizlet.com/_f7689v
D. Both A and B.
E. All of the above.
6. 6. Apoptosis is: **Impaired in
Fas-deficient sys-
A. similar to necrosis. tems**
B. important in peripheral tolerance, but not central
tolerance.
C. important in central tolerance, but not peripheral
tolerance.
D. impaired in Fas-deficient systems.
E. None of the above.
7. 7. Maintaining immunologically protected sites, such **All of the above**
as the eye:
A. allows sequestration of antigens.
B. reduces central tolerance.
C. can lead to autoreactivity secondary to injury.
D. can reduce background reactivity.
E. All of the above.
8. 8. Central tolerance employs all but which of the fol- **Positive Selec-
lowing mechanisms? tion**
A. Apoptosis
B. Receptor editing
C. Positive selection
D. Negative selection
E. Clonal deletion
9. 9. Peripheral tolerance: **Both B and C**
is caused by
A. Is caused by costimulation without TcR-MHC+ pep- TcR-MHC+ pep-
tide interaction. tide interaction
B. is caused by TcR-MHC+ peptide interaction without without costimula-
costimulation. tion.
C. Leads to anergy. Leads to anergy.
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