LIFESCI 2G03 Test 1 UPDATED Questions and CORRECT Answers
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Course
LIFESCI 2G03
Institution
LIFESCI 2G03
LIFESCI 2G03 Test 1 UPDATED
Questions and CORRECT Answers
Huntington's disease is also known as Huntington's chorea - CORRECT ANSWER-
Huntington's chorea
When does the disease begin to appear? - CORRECT ANSWER- 40's and 50's
What are the early symptoms
TRANSITIONAL PHASE - CORRECT ANSWER- -...
LIFESCI 2G03 Test 1 UPDATED
Questions and CORRECT Answers
Huntington's disease is also known as Huntington's chorea - CORRECT ANSWER✔✔-
Huntington's chorea
When does the disease begin to appear? - CORRECT ANSWER✔✔- 40's and 50's
What are the early symptoms
TRANSITIONAL PHASE - CORRECT ANSWER✔✔- - loss of fine motor control
- Slurring speech
what are the later symptoms
ADVANCED PHASE - CORRECT ANSWER✔✔- loss of ability to walk
loss of memory,
speech problems,
patient cannot swallow
How long does it take for the individual to die - CORRECT ANSWER✔✔- Within 15 years
Huntington's disease is late on-set - CORRECT ANSWER✔✔- The phenotypic symptoms
do not start to manifest till later in life so about 40 to 50
These is after they must have had kids
They can pass the allele at any age and it wouldn't be recognized
WHAT IS THE PROGNOSIS - CORRECT ANSWER✔✔- The symptoms will continue to
worsen till the person dies from infection or pneumonia
there is no current treatment
What does complete penetrance mean? - CORRECT ANSWER✔✔- This means that any
person with the mutated gene, they will show the symptoms
, does the mRNA duplicate the coding strand or the template strand - CORRECT
ANSWER✔✔- It duplicates the coding strand but the only difference is that the T is changed
to a U
HOW DO YOU KNOW WHEN IT IS A MISSENSE OR A FRAMESHIFT, IF BOTH
COULD INVOLVE THE INSERTION OF ONE NUCLEOTIDE? - CORRECT
ANSWER✔✔- Missense usually involves the altering of only one nucleotide like changing a
single base pair which leads to a change of one amino acid
Frameshift has to with the insertion or deletion of one or more nucleotides not necessarily the
change of one or two nucleotides (2 extra) and it leads to a change in the rest of the amino
acids after the deletion
insertion of one or two nucleotides could potentially be what mutation - CORRECT
ANSWER✔✔- - missense
- nonsense
- frameshift
The hind 111 is a what? - CORRECT ANSWER✔✔- it is a restrictive enzyme that is cuts
out specific double stranded DNA sequence inthe case of huntington the sequence was
AAGCTT
Where was there a concentration of the disease? - CORRECT ANSWER✔✔- In Venezuela
They took chromosomal DNA tagged it with many radioactivity and looked to see how the
DNA behaving with restriction digest mapping - CORRECT ANSWER✔✔-
restriction fragment length polymorphism - CORRECT ANSWER✔✔- the length of a
restriction fragment, A DNA segment that results from the cutting of DNA by a restriction
enzyme.
2 bands has how many cut sites - CORRECT ANSWER✔✔- 3 cut sites
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