APHON Principles of Chemo and Biotherapy
Biotherapy - ANSWER-Targeted anticancer agents also known as biological response
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWER-Biotherapy
Monoclonal antibodies (MoAbs) are what class - ANSWER-Biotherapy
Define pharmacokinetic...
APHON Principles of Chemo and Biotherapy
Biotherapy - ANSWER-Targeted anticancer agents also known as biological response
modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class - ANSWER-Biotherapy
Monoclonal antibodies (MoAbs) are what class - ANSWER-Biotherapy
Define pharmacokinetics - ANSWER-Study of drug absorption, metabolism, and
excretion
Define pharmacodynamics - ANSWER-The concentration of the drug in the body and
how it produces a response
Define adjuvant chemotherapy - ANSWER-The use of chemo after another type of
therapy, such as surgery, to treat residual disease or undetectable metastasis.
Define neoadjuvant chemotherapy - ANSWER-When chemo is used preoperatively to
decrease tumor burden in order to make it easier to remove the tumor surgically.
Define sanctuary sites - ANSWER-Sites within the body where tumor cells sequester
and are not easily reached by chemo such as the CNS
What normal cells are most often effected by chemotherapy - ANSWER-Hematopoietic,
mucosal (mouth & GI), hair follicles
Why use chemotherapy - ANSWER-To prevent cancer cells from dividing, metastasizing,
and ultimately causing the death of the patient
Cure - ANSWER-To permanently eradicate the cancer
Control - ANSWER-To extend the length & QOL when cure is not feasible or realistic
Palliation - ANSWER-Minimize pain and suffering during end of life
Resting phase of cell cycle - ANSWER-Gap 0 - cells not dividing
Postmitotic phase - ANSWER-Gap 1 - enzymes needed for DNA synthesis are produced,
protein and RNA synthesis takes place (18 Hours)
Synthesis (S) Phase - ANSWER-Cellular DNA duplicated (20 hours)
Premitotic phase - ANSWER-Gap 2 - both protein and RNA synthesis occur, precursors
of mitotic spindle are produced. Shortest phase
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