MGG7010- Exam 1 Grossman Questions
With Correct Answers
Which of the following is defined as the tertiary structure of a protein? - answer✔Structural
domains such as a DNA-binding domain
Monomeric proteins do not contain a: - answer✔quaternary structure
Which of the following is NOT part of a zinc-finger motif? - answer✔Proline Residue
There are many important roles for thee dynamic nature of proteins in a cell. Which of the
following is NOT likely to describe one such reason? - answer✔Quaternary structures are
usually very transient (occur for short periods of time)
You are studying an oligopeptide composed of eight amino acids. The four amino acids nearest
the C terminus are
nonpolar. The two amino acids nearest the N terminus are charged. The middle two amino
acids are polar. Which amino
acid is likely to be labeled as number 2? - answer✔Lysine
A protein containing several proline residues is: - answer✔Not likely to form alpha helices
Which of the following is true about protein folding? - answer✔Elements from the secondary
structures are maintained in the tertiary structures.
When comparing domains and structural motifs, which of the following is NOT true? -
answer✔Structural domains appear in different proteins with similar functions, while structural
motifs have been less conserved over evolution.
You disrupt all hydrogen bonds in a protein. What level of structure will be preserved? -
answer✔Primary
Two proteins that have a similar function: - answer✔will share similar amino acids sequences if
they are homologs
All of the following statements about molecular chaperones are true EXCEPT:
a. they play a role in the proper folding of proteins.
b. they are located in every cellular compartment.
c. they are found only in mammals.
d. they bind a wide range of proteins. - answer✔c. they are found only in mammals
Which of the following does NOT impose limits on protein folding?
a. ability of side chains to form hydrogen and ionic bonds
b. backbone sequence of the polypeptide
c. rotations of the planes around the peptide bonds
d. size of side chains - answer✔b. backbone sequence of the polypeptide
Hsp90 family members are present in all organisms EXCEPT:
a. archaea
b. bacteria
c. fungi
d. plants - answer✔a. archaea
Eggs are protein-rich foods. An uncooked egg can catalyze a reaction that breaks down bacterial
cell walls. After
cooking, this activity is almost abolished. This is likely because: - answer✔The enzyme became
denatured
The correct order for molecular chaperone-mediated protein folding is:
I - exchange of ATP for ADP on chaperone
II - chaperone undergoes conformational change, which affects protein folding
III - chaperone binds to exposed hydrophobic residues on unfolded protein
IV - folded protein is released - answer✔III, II, I, IV
All of the following statements about enzymes are true except:
a. they function in an aqueous environment.
b. they lower the activation energy of a reaction.
c. they increase the rate of a reaction.
d. a single enzyme typically reacts with many different substrates. - answer✔d. a single enzyme
typically reacts with many different substrates
The Km for an enzyme-catalyzed reaction: - answer✔is a measure of the affinity of the
substrate for the enzyme
For an enzyme-catalyzed reaction, doubling the concentration of the enzyme will: -
answer✔double the Vmax
A small molecule that binds directly to the active site of an enzyme and disrupts its catalytic
reaction is called: - answer✔a competitive inhibitor
Changes in the conformational shape of an enzyme that diminish the size of its ligand-binding
pocket are likely to affect an enzyme's: - answer✔specificity and affinity
Which of the following is true about enzymes?
a. The catalytic site is responsible for substrate specificity.
b. Reactions catalyzed by enzymes give the products more free energy than reactions that
occur spontaneously.
c. The rate of an enzymatic reaction is always proportional to the concentration of the
substrate .
d. Enzymes increase reaction rates by lowering the activation energy needed to reach the
transition state. - answer✔d. Enzymes increase reaction rates by lowering the activation energy
needed to reach the transition state
Which of the following plays a role in the degradation of proteins? - answer✔ubiquitin and
proteasome
Which of the following modifications marks a protein for degradation in proteasomes? -
answer✔ubiquitinylation
Protein self-splicing - answer✔is autocatalytic
Proteases that attack selected peptide bonds within a polypeptide chain are synthesized and
secreted as inactive forms called: - answer✔zymogens
Which of the following is a mechanism for regulating protein activity?
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