2. kidneys produce new HCO3 (glutamine = NH4 + HCO3)
where is HCO3 lost? - answer✔-gut
-neutralizing of HCl
when is HCO3- production impacted? - answer✔-when only 30% nephrons remain
-GFR drop by 70%
steps of HCO3 recycling in kidneys - answer✔1. Na from glomerular filtrate goes into tubular
cell
2. H+ from tubular cell goes into glomerular filtrate
3. H+ and HCO3- in glomerular filtrate make H2CO3
4. H2CO3 dissociates into CO2 and H2O
5. H2O and CO2 go back into tubular cell, join to make H2CO3
6. H2CO3 dissociates into HCO3- and H+
7. HCO3- goes into plasma
stimulus to kidney altering HCO3- production - answer✔1. decrease in pH (acidosis) = increase
HCO3-
2. increase in pH (alkalosis) = decrease HCO3-
is renal compensation to pH change ST or LT? - answer✔LT: days to weeks
stimulus to lungs altering pCO2 production - answer✔1. decrease in pH (acidosis) = increase
ventilation, decrease CO2
2. increase in pH (alkalosis) = decrease ventilation, increase CO2
is lung compensation to pH change ST or LT? - answer✔ST: immediate
types of changes in blood pH - answer✔metabolic OR respiratory
normal plasma HCO3- - answer✔22 to 28 mM
metabolic acidosis - answer✔< 22 mM
-indicates deficit in base
-decreases pH
2|Page
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Brightstars. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.49. You're not tied to anything after your purchase.
