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UNE Medical Biochemistry Midterm Exam Questions and Answers
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UNE Medical Biochemistry Midterm Exam Questions and Answers
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UNE Medical Biochemistry MidtermExam Questions and Answers
Which of the following proteins is likely to have quaternary structure? - Answers -A
multimeric protein that contains multiple peptide chains
Prosthetic groups are complex nonprotein molecules that participate in catalysis by
providing functional groups that form a covalent intermediate between the enzyme and
the substrate. Which of the following is an example of a coenzyme or cofactor that
participates in a covalent catalysis reaction? - Answers -Pyridoxal phosphate
Which of the following best describes a protein domain? - Answers -A section of a
protein structure sufficient to perform a particular chemical or physical task
Cleavage of fructose 1,6 bisphosphate to dihydroxyacetone and Glyceraldehyde 3-
phosphate involves the breaking of a carbon-carbon bond through a process other than
oxidation or hydrolysis. This is achieved by what class of enzymes? - Answers -Lyase
A 55-year old man is brought to the emergency room with a chief complaint of chest
pain and tingling in his left arm. Elevation of which of the following enzymes in
circulation would be most indicative of myocardial infarction? - Answers -Troponin
Allosteric activators of hemoglobin will increase substrate binding through which of the
following mechanisms? - Answers -Binding the protein, and keeping it in the "R"
conformation
Which of the following best describes tertiary structure? - Answers -Interactions
between alpha helices and beta sheets to form a domain
How do most enzymes reduce the activation energy needed to move a reaction
forward? - Answers -providing an active site most complementary to the transition state
Domains are common structural elements that retain a particular function within the
protein. Which of the following is an example of a protein domain? - Answers -An
arrangement of beta-strands connected by alpha-helices (beta-alpha-beta-alpha)
Which amino acid would not be commonly found in the middle of an alpha-helical
domain? - Answers -Proline
, Which of the following is a true statement with regards to the malate-aspartate shuttle
system? - Answers -Generates 2.5 molecules of ATP in mitochondria per each NADH
from glycolysis.
Complex II (Succinate Q-reductase) is not considered part of the process of oxidative
phosphorylation because it is unable to do which of the following activities? - Answers -
Pump protons from the mitochondrial matrix into the inter membrane space.
Succinate is a substrate for which complex in the electron transport chain? - Answers -
Complex II (Succinate-Q reductase)
The glycerophosphate shuttle is the major shuttle of most tissues. Which of the
following best describes the transfer of electrons by this shuttle? - Answers -Electrons
are directly transferred from glycerol 3-phosphate to an FAD containing glycerol
phosphate dehydrogenase.
A 19-year old male is being evaluated for muscle weakness. Evaluation of a muscle
biopsy revealed normal rates of succinate oxidation but very low rates of pyruvate
oxidation. Further testing determined normal levels of enzymatic activity in both malate
dehydrogenase and pyruvate dehydrogenase. Based on this data, the patient may have
a mutation in a gene encoding for which mitochondrial protein? - Answers -Complex I
(NADH Q-oxidoreductase)
Which of the following components of the electron transport chain passes electrons to
O2 causing it to be reduced to H2O? - Answers -Cytochrome c oxidase
As electrons flow through complexes in the inner mitochondrial membrane, protons are
pumped from the matrix into the inter membrane space. Which of the following
statements is most reflective of the pH in the inter membrane space? - Answers -The
pH is higher in the matrix when compared to the intermembrane space.
The malate-aspartate shuttle is used to move reducing equivalents o cytosolic NADH
into the mitochondria where it can be oxidized. Which of the following compounds is
used to move the reducing equivalents from cytosolic NADH into the mitochondria? -
Answers -Malate
ATP is a high energy molecule that is often hydrolyzed during reactions. The energy
within ATP is stored primarily in which of the following components of the molecule? -
Answers -In the high energy phosphate bonds
Which of the following is an example of enzyme regulation through covalent
modification? - Answers -phosphorylation of muscle glycogen phosphorylase
Under low energy conditions, AMP will bind to phosphofructokinase I and glycogen
phosphorylase at site unique to the active site. This enhances the activity of these
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