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Enzymology
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Here is the chapter 2 of enzymology notes. it contains notes of the lecture " properties and nature of enzymes" it is the Part#2 of enzymology series
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Enzymology
Enzymology
Part#2
Part#2
2. Enzyme Structure and Composition
Protein nature of enzymes
Active site and substrate binding
Cofactors and coenzymes
2. Enzyme Structure and
Composition
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, 2
A+
Enzymes are intricate biological molecules
whose structure directly dictates their catalytic
function. Understanding their composition and
the roles of various components provides
insight into how they facilitate biochemical
reactions.
Protein Nature of Enzymes
Enzymes are primarily composed of proteins,
which are polymers of amino acids arranged in a
specific sequence. This sequence determines the
enzyme’s three-dimensional structure and,
subsequently, its catalytic activity. Most enzymes
exhibit one or more of the following protein
structures:
1. Primary Structure: The linear sequence of
amino acids linked by peptide bonds.
2.Secondary Structure: Localized folding
patterns such as alpha-helices and beta-sheets,
stabilized by hydrogen bonds.
3. Tertiary Structure: The overall 3D folding
driven by interactions like hydrophobic forces,
ionic bonds, and disulfide bridges.
4. Quaternary Structure: Some enzymes consist
of multiple subunits that form a functional
complex (e.g., haemoglobin).
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