Exam (elaborations)
LAT 2024 QUESTIONS ASND ANSWERS 2024
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Exam of 21 pages for the course LAT at LAT (LAT 2024)
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LAT 2024When developing a new drug what is the correct order of testing? - answer In Vitro,
preclinical, and clinical
How often does the animal welfare regulations require the IACUC to review and do
inspections of the facilities? - answer At least every six months
Which of the agencies regulates disinfectants and sterilizers used on hard surfaces? -
answer United States and environmental protection Agency
What type of floor plan is designed so each room has exit doors to a dirty corridor that
wraps around the periphery of the floor plan? - answer Three-corridor
What is a biofilm? – answer Microorganism build-up on tank wall
What substance can be added to an aquatic system to raise pH? - answer Sodium
bicarbonate
Which parameter is a measure of both calcium and magnesium ions in water? -
answerTotal hardness
AWR (enforced by USDA) require IACUC have how many members? - answerAtleast 3:
Chairperson, vet, and a member not associated with inst.
PHS policy requires how many IACUC members? - answerAt least 5.
Chairperson,vet,scientist,nonscientist, and community member.
Nonfederal research facilities must register with USDA if species are covered by? -
answerAWA. Updates every 3 yrs. signed by IO.
Inst. housing USDA Covered animals must submit a report how often to the USDA? -
answerAnnually
(PHS)
Public health service - answerPublishes the policy on the humane care and use of
laboratory animals.
(AAALAC)
Association for Assessment and Accreditation of Laboratory Animal Care International -
answerProvides peer evaluation of animal care and use programs
,(AWR)
Animal welfare regulation - answerDescribes what a facility must do to comply with the
AWA
(FDA)
Food and drug administration - answerRequires compliance with the good laboratory
practices (GLPs)
(USDA)
U.S. Department of agriculture - answerRegisters institutions using species covered by
animal welfare act
What two federal agencies require compliance with the GLPs? -
answer(EPA)environmental protection agency and (FDA) food and drug admin.
How often must insitutions update registration with USDA if using AWA species? -
answerEvery 3 yrs
What agency enforces the PHS policy? - answer(OLAW)
Office of laboratory animal welfare
What document is signed by IO and is filed to commit the institution to compliance with
the PHS policy? - answerAnimal welfare assurance
What animals are covered under the PHS policy? - answerALL vertebrates
USDA covered animals submit a report to the USDA how often? - answerAnnually
USDA covered species may only be approved for how long? - answer1 year
USDA vet med officers (VMO) conduct unannouced ispections how often? -
answerAtleast annually
IACUCs are mandated by what? - answerFederal mandate
What is a quality assurance unit responsible for ensuring compliance with? -
answerGLP
Which organization uses the GUIDE as one of its standards for accreditation of Lab
animal programs? - answerAAALAC
Most aquatic tanks are made of what plastic? - answerPolycarbonate and polysulfone
Water conductivity is? - answerMeasure of amount of dissolved salts and minerals
Water hardness is the measure of what? - answerSpecific ions dissolved in the water
, What two ions are main ones measured by hardness? - answerCalcium and
magnesium
What percentage of oxygen by volume is in water? - answerLess than 1%
If too many ions in the water, water will flow how in accordance to the animal? -
answerFlow out of the animal
If there are too few ions in the water, the water will flow how in accordance to the
animal? - answerFlow into the animal
What are the three types of vessels? - answerArteries, veins, and capillaries
The contraction phase of the heart is called? - answerSystole
The relaxation phase is called? - answerDiastole
Nodes are found in 5 areas and many tissues: - answerNeck(cervical), rear
leg(popliteal), armpit(axilary), groin area(inguinal)
What acts like an insulator and makes the nerve appear white? - answerMyelin
Which organization uses the guide as one of its standards for accreditation of lab animal
programs? - answerAssociation for assessment and accreditation of lab animal care
(AALAC)
What hormone lowers the blood glucose level? - answerInsulin
If animal was used in experiments, teaching, tests causing pain or distress for which
appropiate anasthetic or tranquilizing drugs were used, what USDA pain category would
it be? - answer"D"
What is the valve between the left atrium and left ventricle of the heart? - answerMitral
valve
What destroys or inactivates infectious fungi and bacteria but not spores? -
answerDisinfectant
Why does the germicidal spectrum of ultraviolet light have to be in a certain wavelength
range? - answerTo limit microorganism replication
Estrous cycle has 4 stages: - answerProestrus, estrus, metestrus, and diestrus
Cat gestation facts: - answer58-67 days. Litters 3-6 kittens. Begin eating solid food at 3-
4 weeks. Weaned at 7-8 weeks.
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