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NR507 Advanced Pathophysiology 2024-2025
NR 507 Advanced Pathophysiology week 7 Final Quiz
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Gout - =Answer>> Inflammatory response to
excessive quantities of uric acid in the blood and other
body fluids, including the synovial fluid
Cause of pain in gout - =Answer>> Elevated uric acid
levels lead to formation of monosodium urate (MSU)
crystals in and around joints and eventually deposited
in connective tissues throughout the body-triggers
release of chemokines and interleukins—crystallization
in synovial fluid causes acute painful inflammation of
the joint which triggers macrophages-prolonged
accumulation results in joint damage
gouty arthritis - =Answer>> Prolonged accumulation
of uric acid resulting in joint damage
degenerative joint disease - =Answer>> characterized
by the wearing away of the articular cartilage within
the joints
osteophytosis - =Answer>> new bone formation of
joint margins
Primary pathogenesis of OA - =Answer>>
Degeneration and eventual loss and disordered repair
of articular cartilage-chondrocytes become damaged
earlier in disease process due to atypical load bearing
paired with genetic/epi genetic and biochemical factors
which lead to increased remodeling of articular
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