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NURS 5315 UTA Exam 2 Questions With Complete Solutions Cytokines Soluble factors that contribute to the regulation of innate or adaptive resistance by affecting other neighboring cells. Can be pro-inflammatory or anti-inflammatory. Can react quickly or be more delayed. Leukotrines Released w...

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  • November 22, 2024
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  • 2024/2025
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NURS 5315 UTA Exam 2
Questions With Complete Solutions

Cytokines Soluble factors that contribute to the regulation of innate or adaptive resistance

by affecting other neighboring cells. Can be pro-inflammatory or anti-inflammatory. Can react

quickly or be more delayed.




Leukotrines Released when mast cells degranulate, prolong the inflammatory process.

Cause vasodilation, attract neutrophils, monocytes, and eosinophils.target of inhibition for

singular.




Prostaglandins Released when mast cells degranulate, are produced by the arachidonic

pathway. Cause vasodilation, platelet aggregation at site of injury, pain, and fever.




Chemotactic factors Biochemical substance that attracts leukocyte to the site of

inflammation

, NURS 5315 UTA Exam 2
Questions With Complete Solutions
Neutrophils Predominant leukocyte at work during the early stages of acute inflammation




Monocytes Become macrophages when entering the tissue, responsible for presenting

antigens to the CD4 cell which triggers T-cell immunity and B-cell immunity.

Releases additional cytokines IL1, IL6, TNF.




Cytokine IL1 function Causes fever, activates phagocytes & lymphocytes and also

increases the release of IL6a




Cytokine IL6 function Stimulates production of acute phase reactants and promotes

growth and stimulation of RBCs




Cytokine TNF function Causes fever, increases synthesis of proinflammatory proteins by

liver, causes muscle wasting, induces thrombosis

, NURS 5315 UTA Exam 2
Questions With Complete Solutions

Cytokine growth factor function Promotes production and maturation of neutrophils




Complement Functions include bacterial lysis, vasodilation and increased vascular

permeability, triggers mast cell degranulation, chemotaxis, and opsonization.




Kinin Converted to bradykinin which is responsible for pain and chemotaxis, and it

increases vascular permeability and vasodilation.




Coagulation cascade Factor XII activates kinin. Function is to form fibrin mesh to stop

bleeding and trap micro organisms.




COX1 Prostaglandin of arachidonic pathway. Provides gastroprotection, platelet

aggregation, fluid/electrolyte balance

, NURS 5315 UTA Exam 2
Questions With Complete Solutions

COX2 Prostaglandin of arachidonic pathway. Responsible for pain, fever, renal

protection, tissue repair, reproduction development.




COX2 inhibitors- clinical implications Protect gastric mucosa- prevent ulcers and

bleeding. Removed from market r/t cardiac events except for Celebrex. Can impair renal

function , monitor labs.




Arachidonic pathway purpose Synthesis of prostaglandins




Non-selective NSAIDS Inhibit COX1 and COX2, risk for gastric ulceration, GI bleeds,

edema, renal impairment




ASA Blocks COX1 and COX2, also inhibits Thromboxane A2 and prostaglandins

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