NSG322 Bipolar Disorder Meds: Questions With
Complete Solutions
What are the first-line treatments for bipolar disorder? Right Ans - -
Lithium
- Anticonvulsants: Valproate, lamotrigine, carbamazepine
What meds can treat agitation associated with bipolar disorder? Right Ans
- - Lithium, divalproex, olanzapine, risperidone
- Benzodiazepines (clonazepam, lorazepam) for short-term agitation caused
by acute mania
What med can be used for mood stabilization in patients with bipolar
disorder? Right Ans - Lithium - GOLD STANDARD FOR MANIA, FIRST-LINE
TREATMENT
Lithium (MOA) Right Ans - - Interact with sodium and potassium to
stabilize electrical activity
- Reduce glutamate activity - Antimanic effect
- Antidepressant properties
- Antisuicidal properties
Lithium (indications) Right Ans - FDA approved for acute mania and
maintenance treatment of bipolar disorder
Lithium is particularly effective in reducing Right Ans - - Elation,
grandiosity, expansiveness
- Flights of ideas
- Irritability and manipulation
- Anxiety
- Self-injurious behavior
Lithium (onset) Right Ans - 10-21 days; supplement in early phases with
second-generation antipsychotics, anticonvulsants, & antianxieties until reach
full therapeutic effect
Lithium (therapeutic index) Right Ans - - Narrow therapeutic index
, - Must reach therapeutic blood levels to be effective (7-14 days or longer to
reach)
- Target 12-hr serum trough level is 0.8-1.2
- Clinical benefit level for acute mania is 1.0-1.2
- Maintenance level is 0.6-0.8
=> FREQUENT MONITORING OF LABS IS CRUCIAL (TOXICITY &
THERAPEUTIC EFFECT)
When should the first lithium level be drawn? Right Ans - Every 2 to 3 days
after begin therapy and after any dosage change until therapeutic level has
been reached
How often should blood levels be checked after therapeutic level has been
reached? Right Ans - Every 3-6 months
What should the nurse teach older patients on lithium? Right Ans - Start
low and go slow
What should be done before administering lithium? Right Ans - Baseline
assessment of renal function, thyroid status (thyroxine and TSH levels), labs,
ECG
Lithium (contraindications) Right Ans - CVD, brain damage, renal disease,
thyroid disease, myasthenia gravis, pregnancy, breast-feeding, children <12yo
Lithium (adverse effects) Right Ans - - Skin: acne, alopecia, psoriasis
- GI: N/V, DIARRHEA
- Endocrine: HYPOTHYROIDISM, WEIGHT GAIN
- Fluid and electrolyte: edema, POLYDIPSIA, POLYURIA
- Nervous and musculoskeletal: ATAXIA, SEDATION, FINE TREMOR
Lithium serum level <1.5 (signs of toxicity) Right Ans - - N/V, DIARRHEA,
thirst, POLYURIA, lethargy, sedation, FINE HAND TREMOR
- Renal toxicity, goiter, and hypothyroidism may occur with long-term use
Lithium serum level <1.5 (interventions) Right Ans - - Symptoms often
subside during treatment.
- DOSES SHOULD BE KEPT LOW.
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