Psychopharmacology NSG 552 Exam 3 – Questions &
Accurate Solutions
Naloxone (Narcan) Right Ans - opiate antagonist, reverses opioid induced
respiratory depression
Treatment of choice for all patients with opioid use disorder
Very short half-life
What is Methadone also known as? Right Ans - Dolophine
What type of opioid receptor agonist is Methadone? Right Ans - Long-
acting full agonist at the mu receptor
How often is Methadone dosed? Right Ans - Once daily
In what type of programs is Methadone use restricted? Right Ans -
Federally licensed substance abuse treatment programs
What should be monitored when using Methadone? Right Ans - QTC
prolongation
What is Buprenorphine (Buprenex, Sublocade)? Right Ans - Partial Opioid
receptor agonist
What is the function of Buprenorphine/Naloxone (Suboxone)? Right Ans -
Opioid antagonist
What effect does Buprenorphine have on cravings? Right Ans - Decreases
cravings
What precaution is needed when using Suboxone in outpatient settings?
Right Ans - Waiver needed to prescribe in outpatient settings
What can happen if Buprenorphine is used too soon after a full opioid agonist?
Right Ans - Can precipitate withdrawal
How does Suboxone interact with residual opioids from mu receptors?
Right Ans - It will displace any residual opioids from the mu receptors
,What is the route of administration for Suboxone? Right Ans - Sublingual
preparation
In what situation can Suboxone be used in managing pain? Right Ans -
Opioid Use disorder w/ comorbid pain
What type of antagonist is Naltrexone? Right Ans - Competitive opioid
antagonist
What can happen if Naltrexone is used within 7 days of heroin use? Right
Ans - Precipitate withdrawal
How is Naltrexone available for use? Right Ans - Orally or monthly depot
injection
When is Naltrexone considered the treatment of choice? Right Ans - For
highly motivated patients
What is a potential risk associated with Naltrexone use? Right Ans - Risk
for LFT elevation
Naltrexone Right Ans - Available PO (Revia) Available IM (Vivitrol)
Buprenorphine (Buprenex, Sublocade) Buprenorphine/Naloxone (Suboxone)
Right Ans - Suboxone= available Buccal film, sublingual film, sublingual tab
Buprenorphine= Available sublingual tab; subdermal implant, SQ injection
What are the common symptoms of opioid overdose? Right Ans - Miosis,
Hypotension, Bradycardia, Low RR, Unconsciousness
How is opioid overdose managed? Right Ans - Naloxone
What are the symptoms of opioid withdrawal? Right Ans - Anxiety,
Lacrimation, Muscle aches, Abdominal cramps, Diarrhea, Seizures
What medications are used for opioid withdrawal management? Right Ans
- Buprenorphine/naloxone, Clonidine, Bentyl
, In opioid detoxification, which medication is more effective at suppressing
withdrawal symptoms towards the end of the taper? Right Ans -
Buprenorphine (compared to methadone)
What are some symptoms of cocaine use? Right Ans - Auditory
hallucinations, agitation, violent behavior, muscle twitching, hypertension,
tachycardia
How is lorazepam used in the treatment of cocaine use disorder? Right Ans
- It is used to treat agitation and muscle twitching associated with cocaine use
How does Antabuse work in the treatment of cocaine use disorder? Right
Ans - It increases synaptic dopamine in the brain reward circuit and acts as an
agonist treatment
What medications are used for cocaine-induced chest pain and myocardial
infarction? Right Ans - Nitroglycerin and Aspirin
Why is Metoprolol contraindicated in patients with cocaine-induced chest
pain? Right Ans - It further lowers coronary blood flow, worsening
ischemia
alcohol use disorder Right Ans - alcohol use marked by tolerance,
withdrawal, and a drive to continue problematic use
What are the symptoms of mild Alcohol Use Disorder? Right Ans -
Insomnia, Irritability, Hand tremor
What are the symptoms of moderate Alcohol Use Disorder? Right Ans -
Autonomic hyperactivity (diaphoresis, tachycardia, hypertension), Fever
What are the symptoms of severe Alcohol Use Disorder? Right Ans -
Seizures (12-48 hours post consumption), Hallucinations, Delirium Tremens
(48-96 hours after last drink)
What are the physical symptoms of Alcohol Use Disorder? Right Ans -
Impaired fine motor control, Ataxic gait and poor balance, Lethargy,
Nausea/Vomiting, Respiratory depression
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