Psychopharmacology (Antipsychotics, Mood
stabilizers, Antidepressants, Sedative/hypnotics) – Q’s
And A’s
What is the MOA of antipsychotics? Right Ans - Dopamine receptor
antagonists
What are the two classes of antipsychotics? Right Ans - Typicals -
antagonize D2 only, greater risk of side effects
Atypicals - antagonize D2, D4, and 5HTZ, favorable for long term treatment
*Risperidone [Risperdal] - atypical, only acts on D2 and 5HTz
Typical Antipsychotic Rx Right Ans - Haloperidol [Haldol], Chlorpromazine
[Thorazine], Prochlorperazine [Compazine], Fluphenazine [Prolixin]
Atypical Antipsychotic Rx Right Ans - Risperidone [Risperdal]
Olanzapine [Zyprexa]
Quetiapine [Seroquel]
Clozapine [Clozaril]
Ziprasidone [Geodon]
Aripiprazole [Abilify]
What are the indications for antipsychotic therapy? Right Ans - 1. Psychotic
disorders
2. Acute agitation - haloperidol, ziprasidone
3. Mood disorders - MDD, BP2 - adjunct to SSRI, esp. Aripiprazole
4. Movement d/o involving excessive dopaminergic stimulation (i.e.
Huntington's, Tourette's)
Which antipsychotic is associated with agranulocytosis? Right Ans -
Clozapine [Clozaril]
Which antipsychotic is associated with prolongation of QT interval? Right
Ans - Ziprasidone [Geodon]
Which antipsychotic is the least sedating? Right Ans - Risperidone
[Risperdal]
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