NAPLEX 2024 QUESTIONS AND CORRECT
ANSWERS LATEST UPLOAD 2024/2025 BEST
EXAM SOLUTION RATED A+ FOR SUCCESS
Key drugs that can cause hypothyroidism - CORRECT ANSWERS "I TALC"
Hyperthyroid in pregnancy - CORRECT ANSWERS Hyperthyroidism during pregnancy
should be treated with propylthiouracil (PTU) during the first trimester then methimazole
during the second and third trimesters. Although methimazole is a teratogen, the teratogenic
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effects are less during the second and third trimesters, and PTU can cause liver failure,
which is why it is substituted out.
Cushing's syndrome - CORRECT ANSWERS Adrenal gland produces too much cortisol or
exogenous steroids are taken in doses higher than normal amounts of endogenous cortisol
Addison's disease - CORRECT ANSWERS a condition that occurs when the adrenal
glands do not produce enough cortisol; Addisonian crisis (volume depletion and hypotension,
which can be fatal)
Steroids: least to most potent - CORRECT ANSWERS (Cute Hot Pharmacists and
Physicians Marry Together & Deliver Babies)
o Cortisone (25 mg): short acting
o Hydrocortisone (20 mg): short acting
o Prednisone (5 mg): intermediate acting
o Prednisolone (5 mg): intermediate acting
o Methylprednisolone (4 mg): intermediate acting
o Triamcinolone (4 mg): intermediate acting
o Dexamethasone (0.75 mg): long acting, highest potency
o Betamethasone (0.6 mg): long acting, highest potency
Immunosuppression from steroids - CORRECT ANSWERS A patient is immunosuppressed
when using >/= 2mg/kg/day or >/= 20mg/day of prednisone or prednisone equivalent for >2
weeks
Immunosuppressed patients cannot receive live vaccines and have a high risk of infection
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steroid will need to be slowly tapered off: reduce 10-20% every few days (tapers can last 7-
14 days, longer or shorter)
Traditional DMARDs (disease modifying anti-rheumatic drugs) - CORRECT ANSWERS
MTX (Trexall): first line in RA
Hydroxychloroquine (Plaquenil)
Sulfasalazine
Leflunomide (Arava)
Traditional DMARDs (disease modifying anti-rheumatic drugs): MTX - CORRECT
ANSWERS MTX (Trexall): first line in RA
- irreversibly binds and inhibit dihydrofolate reductase, inhibiting folate
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