GMS6552 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
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Course
GMS6552
Institution
GMS6552
GMS6552 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
Most common Drug Target
Receptors
Time frame for Channel-linked Receptors
Milliseconds
Class name for Channel-linked Receptors
Ionotropic receptors
Example of Channel-linked Receptors
Nicotinic/ACh Receptors
...
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GMS6552 EXAM QUESTIONS AND ANSWERS WITH COMPLETE
SOLUTIONS VERIFIED LATEST UPDATE
Most common Drug Target
Receptors
Time frame for Channel-linked Receptors
Milliseconds
Class name for Channel-linked Receptors
Ionotropic receptors
Example of Channel-linked Receptors
Nicotinic/ACh Receptors
Time frame for GPCRs
Seconds
Class name for GPCRs
Metabotropic Receptors
Example of GPCRs
Muscarinic/ACh Receptors
Time frame for Kinase-linked Receptors
Minutes
Insulin receptors fall under which type of receptor category?
Kinase-linked Receptors
How long does it take for insulin to take effect?
Minutes
,Time frame of Nuclear receptors
Hours to Days
How many transmembrane domains are there on GPCRs?
7
The alpha subunit of G protein is what type of enzyme?
GTPase (slow)
The G-proteins are [intracellular or extracellular]?
intracellular, but membrane associated
The N-terminus of the GPCR is
Extracellular
The C-terminus of the GPCR is
Intracellular
When what is bound to alpha subunit, are the g proteins turned on?
GTP
alpha S subunit of G protein activates
adenylyl cyclase
Adenylyl cyclase increases
cAMP
cAMP activates
PKA
alpha I subunit of G proteins inhibits
Adenylyl cyclase
alpha q subunit of G protein activates
, PLC
PLC increases levels of what two things?
DAG and IP3
IP3 increases levels of intracellular _________
Calcium
DAG activates
PKC
T/F: There are no 2nd messengers in Kinase-linked receptor signaling
True
In receptors associated w/ cytosolic kinases:
Receptors are initially _____________________
once ligand binds, they _______________________
After that, ________ gets activated which will phosphorylate __________
residues.
monomeric; dimerize; JAK; Tyrosine
In receptors associated w/ cytosolic kinases, proteins with _______ domains
(such as STAT, SHC, GRB2, PI3K) bind and gets activated via ______________ of
those residues. Once activated, they act as __________________ and translocate
to the ______________.
SH2; phosphorylation; Trxn factors; nucleus
Receptor tyrosine kinases have ____________________ tyrosine kinase activity.
Intrinsic
T/F: Insulin acts on receptor tyrosine kinases.
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